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Altered functional connectivity architecture of the brain in medication overuse headache using resting state fMRI
BACKGROUND: Functional connectivity density (FCD) could identify the abnormal intrinsic and spontaneous activity over the whole brain, and a seed-based resting-state functional connectivity (RSFC) could further reveal the altered functional network with the identified brain regions. This may be an e...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Milan
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318354/ https://www.ncbi.nlm.nih.gov/pubmed/28220377 http://dx.doi.org/10.1186/s10194-017-0735-0 |
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author | Chen, Zhiye Chen, Xiaoyan Liu, Mengqi Dong, Zhao Ma, Lin Yu, Shengyuan |
author_facet | Chen, Zhiye Chen, Xiaoyan Liu, Mengqi Dong, Zhao Ma, Lin Yu, Shengyuan |
author_sort | Chen, Zhiye |
collection | PubMed |
description | BACKGROUND: Functional connectivity density (FCD) could identify the abnormal intrinsic and spontaneous activity over the whole brain, and a seed-based resting-state functional connectivity (RSFC) could further reveal the altered functional network with the identified brain regions. This may be an effective assessment strategy for headache research. This study is to investigate the RSFC architecture changes of the brain in the patients with medication overuse headache (MOH) using FCD and RSFC methods. METHODS: 3D structure images and resting-state functional MRI data were obtained from 37 MOH patients, 18 episodic migraine (EM) patients and 32 normal controls (NCs). FCD was calculated to detect the brain regions with abnormal functional activity over the whole brain, and the seed-based RSFC was performed to explore the functional network changes in MOH and EM. RESULTS: The decreased FCD located in right parahippocampal gyrus, and the increased FCD located in left inferior parietal gyrus and right supramarginal gyrus in MOH compared with NC, and in right caudate and left insula in MOH compared with EM. RSFC revealed that decreased functional connectivity of the brain regions with decreased FCD anchored in the right dorsal-lateral prefrontal cortex, right frontopolar cortex in MOH, and in left temporopolar cortex and bilateral visual cortices in EM compared with NC, and in frontal-temporal-parietal pattern in MOH compared with EM. CONCLUSIONS: These results provided evidence that MOH and EM suffered from altered intrinsic functional connectivity architecture, and the current study presented a new perspective for understanding the neuromechanism of MOH and EM pathogenesis. |
format | Online Article Text |
id | pubmed-5318354 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Springer Milan |
record_format | MEDLINE/PubMed |
spelling | pubmed-53183542017-03-07 Altered functional connectivity architecture of the brain in medication overuse headache using resting state fMRI Chen, Zhiye Chen, Xiaoyan Liu, Mengqi Dong, Zhao Ma, Lin Yu, Shengyuan J Headache Pain Research Article BACKGROUND: Functional connectivity density (FCD) could identify the abnormal intrinsic and spontaneous activity over the whole brain, and a seed-based resting-state functional connectivity (RSFC) could further reveal the altered functional network with the identified brain regions. This may be an effective assessment strategy for headache research. This study is to investigate the RSFC architecture changes of the brain in the patients with medication overuse headache (MOH) using FCD and RSFC methods. METHODS: 3D structure images and resting-state functional MRI data were obtained from 37 MOH patients, 18 episodic migraine (EM) patients and 32 normal controls (NCs). FCD was calculated to detect the brain regions with abnormal functional activity over the whole brain, and the seed-based RSFC was performed to explore the functional network changes in MOH and EM. RESULTS: The decreased FCD located in right parahippocampal gyrus, and the increased FCD located in left inferior parietal gyrus and right supramarginal gyrus in MOH compared with NC, and in right caudate and left insula in MOH compared with EM. RSFC revealed that decreased functional connectivity of the brain regions with decreased FCD anchored in the right dorsal-lateral prefrontal cortex, right frontopolar cortex in MOH, and in left temporopolar cortex and bilateral visual cortices in EM compared with NC, and in frontal-temporal-parietal pattern in MOH compared with EM. CONCLUSIONS: These results provided evidence that MOH and EM suffered from altered intrinsic functional connectivity architecture, and the current study presented a new perspective for understanding the neuromechanism of MOH and EM pathogenesis. Springer Milan 2017-02-20 /pmc/articles/PMC5318354/ /pubmed/28220377 http://dx.doi.org/10.1186/s10194-017-0735-0 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Research Article Chen, Zhiye Chen, Xiaoyan Liu, Mengqi Dong, Zhao Ma, Lin Yu, Shengyuan Altered functional connectivity architecture of the brain in medication overuse headache using resting state fMRI |
title | Altered functional connectivity architecture of the brain in medication overuse headache using resting state fMRI |
title_full | Altered functional connectivity architecture of the brain in medication overuse headache using resting state fMRI |
title_fullStr | Altered functional connectivity architecture of the brain in medication overuse headache using resting state fMRI |
title_full_unstemmed | Altered functional connectivity architecture of the brain in medication overuse headache using resting state fMRI |
title_short | Altered functional connectivity architecture of the brain in medication overuse headache using resting state fMRI |
title_sort | altered functional connectivity architecture of the brain in medication overuse headache using resting state fmri |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318354/ https://www.ncbi.nlm.nih.gov/pubmed/28220377 http://dx.doi.org/10.1186/s10194-017-0735-0 |
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