Cargando…

Lanthionine Synthetase C-Like 2 Modulates Immune Responses to Influenza Virus Infection

Broad-based, host-targeted therapeutics have the potential to ameliorate viral infections without inducing antiviral resistance. We identified lanthionine synthetase C-like 2 (LANCL2) as a new therapeutic target for immunoinflammatory diseases. To examine the therapeutic efficacy of oral NSC61610 ad...

Descripción completa

Detalles Bibliográficos
Autores principales:	Leber, Andrew, Bassaganya-Riera, Josep, Tubau-Juni, Nuria, Zoccoli-Rodriguez, Victoria, Lu, Pinyi, Godfrey, Victoria, Kale, Shiv, Hontecillas, Raquel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318425/ https://www.ncbi.nlm.nih.gov/pubmed/28270815 http://dx.doi.org/10.3389/fimmu.2017.00178

Ejemplares similares

Modeling the Role of Lanthionine Synthetase C-Like 2 (LANCL2) in the Modulation of Immune Responses to Helicobacter pylori Infection
por: Leber, Andrew, et al.
Publicado: (2016)

NLRX1 Modulates Immunometabolic Mechanisms Controlling the Host–Gut Microbiota Interactions during Inflammatory Bowel Disease
por: Leber, Andrew, et al.
Publicado: (2018)

Nlrx1-Regulated Defense and Metabolic Responses to Aspergillus fumigatus Are Morphotype and Cell Type Specific
por: Kastelberg, Bridget, et al.
Publicado: (2021)

Abscisic acid enriched fig extract promotes insulin sensitivity by decreasing systemic inflammation and activating LANCL2 in skeletal muscle
por: Leber, Andrew, et al.
Publicado: (2020)

Computational Modeling-Based Discovery of Novel Classes of Anti-Inflammatory Drugs That Target Lanthionine Synthetase C-Like Protein 2
por: Lu, Pinyi, et al.
Publicado: (2012)

Computational modeling of complex bioenergetic mechanisms that modulate CD4+ T cell effector and regulatory functions
por: Baker, Ryan, et al.
Publicado: (2022)

Modeling-Enabled Characterization of Novel NLRX1 Ligands
por: Lu, Pinyi, et al.
Publicado: (2015)

NLRX1 is a key regulator of immune signaling during invasive pulmonary aspergillosis
por: Kastelberg, Bridget, et al.
Publicado: (2020)

First-in-class topical therapeutic omilancor ameliorates disease severity and inflammation through activation of LANCL2 pathway in psoriasis
por: Tubau-Juni, Nuria, et al.
Publicado: (2021)

Identification of new regulatory genes through expression pattern analysis of a global RNA-seq dataset from a Helicobacter pylori co-culture system
por: Tubau-Juni, Nuria, et al.
Publicado: (2020)

Modulation of colonic immunometabolic responses during Clostridioides difficile infection ameliorates disease severity and inflammation
por: Tubau-Juni, Nuria, et al.
Publicado: (2023)

Abscisic Acid: A Novel Nutraceutical for Glycemic Control
por: Zocchi, Elena, et al.
Publicado: (2017)

Challenges in Personalized Nutrition and Health
por: Verma, Meghna, et al.
Publicado: (2018)

Modeling-Enabled Systems Nutritional Immunology
por: Verma, Meghna, et al.
Publicado: (2016)

High-resolution computational modeling of immune responses in the gut
por: Verma, Meghna, et al.
Publicado: (2019)

Modulation of Immune Signaling and Metabolism Highlights Host and Fungal Transcriptional Responses in Mouse Models of Invasive Pulmonary Aspergillosis
por: Kale, Shiv D., et al.
Publicado: (2017)

Preventive and Prophylactic Mechanisms of Action of Pomegranate Bioactive Constituents
por: Viladomiu, Monica, et al.
Publicado: (2013)

Supervised learning methods in modeling of CD4+ T cell heterogeneity
por: Lu, Pinyi, et al.
Publicado: (2015)

Discovery of Unique Lanthionine Synthetases Reveals New Mechanistic and Evolutionary Insights
por: Goto, Yuki, et al.
Publicado: (2010)

Lanthionine synthetase C–like protein 2 (LanCL2) is a novel regulator of Akt
por: Zeng, Min, et al.
Publicado: (2014)

Treatment of Obesity-Related Complications with Novel Classes of Naturally Occurring PPAR Agonists
por: Bassaganya-Riera, Josep, et al.
Publicado: (2011)

Dietary α-Eleostearic Acid Ameliorates Experimental Inflammatory Bowel Disease in Mice by Activating Peroxisome Proliferator-Activated Receptor-γ
por: Lewis, Stephanie N., et al.
Publicado: (2011)

Systems Modeling of Interactions between Mucosal Immunity and the Gut Microbiome during Clostridium difficile Infection
por: Leber, Andrew, et al.
Publicado: (2015)

Modeling the Mechanisms by Which HIV-Associated Immunosuppression Influences HPV Persistence at the Oral Mucosa
por: Verma, Meghna, et al.
Publicado: (2017)

Multiscale modeling of mucosal immune responses
por: Mei, Yongguo, et al.
Publicado: (2015)

Dietary Modulation of Inflammation-Induced Colorectal Cancer through PPARγ
por: Carter, Ashlee B., et al.
Publicado: (2009)

Gene regulatory network reveals oxidative stress as the underlying molecular mechanism of type 2 diabetes and hypertension
por: Jesmin, et al.
Publicado: (2010)

Mechanistic Studies of Ser/Thr Dehydration Catalyzed by a Member of the LanL Lanthionine Synthetase Family†
por: Goto, Yuki, et al.
Publicado: (2011)

Abscisic Acid Standardized Fig (Ficus carica) Extracts Ameliorate Postprandial Glycemic and Insulinemic Responses in Healthy Adults
por: Atkinson, Fiona S., et al.
Publicado: (2019)

Immunoregulatory Mechanisms Underlying Prevention of Colitis-Associated Colorectal Cancer by Probiotic Bacteria
por: Bassaganya-Riera, Josep, et al.
Publicado: (2012)

The Role of T cell PPAR γ in mice with experimental inflammatory bowel disease
por: Guri, Amir J, et al.
Publicado: (2010)

Substrate Control in Stereoselective Lanthionine Biosynthesis
por: Tang, Weixin, et al.
Publicado: (2014)

Variants at the MHC Region Associate With Susceptibility to Clostridioides difficile Infection: A Genome-Wide Association Study Using Comprehensive Electronic Health Records
por: Li, Jiang, et al.
Publicado: (2021)

Computational modeling of heterogeneity and function of CD4+ T cells
por: Carbo, Adria, et al.
Publicado: (2014)

The Sequence of the Enterococcal Cytolysin Imparts Unusual Lanthionine Stereochemistry
por: Tang, Weixin, et al.
Publicado: (2013)

LanCL proteins are not Involved in Lanthionine Synthesis in Mammals
por: He, Chang, et al.
Publicado: (2017)

Emerging Biological Importance of Central Nervous System Lanthionines
por: Hensley, Kenneth, et al.
Publicado: (2010)

The Role of Peroxisome Proliferator-Activated Receptor γ in Immune Responses to Enteroaggregative Escherichia coli Infection
por: Philipson, Casandra W., et al.
Publicado: (2013)

Systems Modeling of Molecular Mechanisms Controlling Cytokine-driven CD4+ T Cell Differentiation and Phenotype Plasticity
por: Carbo, Adria, et al.
Publicado: (2013)

Biosynthesis of lanthionine-constrained agonists of G protein-coupled receptors
por: Moll, Gert N., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_qrgekhm40fi0a5u7vbm6t4ndp1