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Pharmacokinetics of Standard- and Reduced-Dose Recombinant Human Soluble Thrombomodulin in Patients with Septic Disseminated Intravascular Coagulation during Continuous Hemodiafiltration

INTRODUCTION: Recombinant human soluble thrombomodulin (rTM) is reportedly excreted by the kidneys; therefore, the recommended dose for patients with renal impairment is one-third of the standard dose. The aim of this study was to evaluate whether this reduced dose of rTM achieves effective drug con...

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Detalles Bibliográficos
Autores principales:	Watanabe, Eizo, Yamazaki, Shingo, Setoguchi, Daisuke, Sadahiro, Tomohito, Tateishi, Yoshihisa, Suzuki, Tatsuya, Ishii, Itsuko, Oda, Shigeto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318446/ https://www.ncbi.nlm.nih.gov/pubmed/28271063 http://dx.doi.org/10.3389/fmed.2017.00015

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