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Secondary Cutaneous Amyloidosis in a Patient with Mycosis Fungoides
Secondary cutaneous amyloidosis refers to clinically unapparent amyloid deposits within the skin in association with a pre-existing skin condition or skin tumors, such as basal cell carcinoma, porokeratosis, solar elastosis, Bowen's disease, and mycosis fungoides. A 70-year-old woman presented...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Korean Dermatological Association; The Korean Society for Investigative Dermatology
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318532/ https://www.ncbi.nlm.nih.gov/pubmed/28223751 http://dx.doi.org/10.5021/ad.2017.29.1.79 |
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author | Nam, Chan Hee Park, Min Kee Choi, Mi Soo Hong, Seung Phil Park, Byung Cheol Kim, Myung Hwa |
author_facet | Nam, Chan Hee Park, Min Kee Choi, Mi Soo Hong, Seung Phil Park, Byung Cheol Kim, Myung Hwa |
author_sort | Nam, Chan Hee |
collection | PubMed |
description | Secondary cutaneous amyloidosis refers to clinically unapparent amyloid deposits within the skin in association with a pre-existing skin condition or skin tumors, such as basal cell carcinoma, porokeratosis, solar elastosis, Bowen's disease, and mycosis fungoides. A 70-year-old woman presented with a 6-month history of asymptomatic multiple yellowish plaques on both legs. She had been diagnosed with mycosis fungoides 7 years ago and was treated with psoralen and ultraviolet A radiation (PUVA) therapy, narrow-band ultraviolet B (UVB) therapy, and acitretin for 5 years. Finally, she reached complete remission of mycosis fungoides. However, new yellowish lesions started to appear 1 year after discontinuing the phototherapy. A physical examination revealed multiple yellowish plaques on both extremities. The plaques were well circumscribed and slightly elevated. All laboratory tests were normal. A biopsy specimen showed multiple nodular deposits of eosinophilic amorphous material in papillary dermis and upper reticular dermis. The deposits represented apple green birefringence on Congo red stain viewed under polarized light. Acellular small nodules in the upper dermis consisted of randomly oriented, non-branching, 6.67~12.7 nm thick amyloid fibrils on electron microscopy. We report an interesting and rare case of secondary cutaneous amyloidosis after narrow-band UVB therapy and PUVA therapy in a patient with mycosis fungoides. |
format | Online Article Text |
id | pubmed-5318532 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | The Korean Dermatological Association; The Korean Society for Investigative Dermatology |
record_format | MEDLINE/PubMed |
spelling | pubmed-53185322017-02-21 Secondary Cutaneous Amyloidosis in a Patient with Mycosis Fungoides Nam, Chan Hee Park, Min Kee Choi, Mi Soo Hong, Seung Phil Park, Byung Cheol Kim, Myung Hwa Ann Dermatol Case Report Secondary cutaneous amyloidosis refers to clinically unapparent amyloid deposits within the skin in association with a pre-existing skin condition or skin tumors, such as basal cell carcinoma, porokeratosis, solar elastosis, Bowen's disease, and mycosis fungoides. A 70-year-old woman presented with a 6-month history of asymptomatic multiple yellowish plaques on both legs. She had been diagnosed with mycosis fungoides 7 years ago and was treated with psoralen and ultraviolet A radiation (PUVA) therapy, narrow-band ultraviolet B (UVB) therapy, and acitretin for 5 years. Finally, she reached complete remission of mycosis fungoides. However, new yellowish lesions started to appear 1 year after discontinuing the phototherapy. A physical examination revealed multiple yellowish plaques on both extremities. The plaques were well circumscribed and slightly elevated. All laboratory tests were normal. A biopsy specimen showed multiple nodular deposits of eosinophilic amorphous material in papillary dermis and upper reticular dermis. The deposits represented apple green birefringence on Congo red stain viewed under polarized light. Acellular small nodules in the upper dermis consisted of randomly oriented, non-branching, 6.67~12.7 nm thick amyloid fibrils on electron microscopy. We report an interesting and rare case of secondary cutaneous amyloidosis after narrow-band UVB therapy and PUVA therapy in a patient with mycosis fungoides. The Korean Dermatological Association; The Korean Society for Investigative Dermatology 2017-02 2017-02-03 /pmc/articles/PMC5318532/ /pubmed/28223751 http://dx.doi.org/10.5021/ad.2017.29.1.79 Text en Copyright © 2017 The Korean Dermatological Association and The Korean Society for Investigative Dermatology http://creativecommons.org/licenses/by-nc/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Nam, Chan Hee Park, Min Kee Choi, Mi Soo Hong, Seung Phil Park, Byung Cheol Kim, Myung Hwa Secondary Cutaneous Amyloidosis in a Patient with Mycosis Fungoides |
title | Secondary Cutaneous Amyloidosis in a Patient with Mycosis Fungoides |
title_full | Secondary Cutaneous Amyloidosis in a Patient with Mycosis Fungoides |
title_fullStr | Secondary Cutaneous Amyloidosis in a Patient with Mycosis Fungoides |
title_full_unstemmed | Secondary Cutaneous Amyloidosis in a Patient with Mycosis Fungoides |
title_short | Secondary Cutaneous Amyloidosis in a Patient with Mycosis Fungoides |
title_sort | secondary cutaneous amyloidosis in a patient with mycosis fungoides |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318532/ https://www.ncbi.nlm.nih.gov/pubmed/28223751 http://dx.doi.org/10.5021/ad.2017.29.1.79 |
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