Lineage-Specific Genes Are Prominent DNA Damage Hotspots during Leukemic Transformation of B Cell Precursors

In human leukemia, lineage-specific genes represent predominant targets of deletion, with lymphoid-specific genes frequently affected in lymphoid leukemia and myeloid-specific genes in myeloid leukemia. To investigate the basis of lineage-specific alterations, we analyzed global DNA damage in primar...

Descripción completa

Detalles Bibliográficos
Autores principales: Boulianne, Bryant, Robinson, Mark E., May, Philippa C., Castellano, Leandro, Blighe, Kevin, Thomas, Jennifer, Reid, Alistair, Müschen, Markus, Apperley, Jane F., Stebbing, Justin, Feldhahn, Niklas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318656/
https://www.ncbi.nlm.nih.gov/pubmed/28199841
http://dx.doi.org/10.1016/j.celrep.2017.01.057

Ejemplares similares

Ejemplares similares