FOXM1 allows human keratinocytes to bypass the oncogene-induced differentiation checkpoint in response to gain of MYC or loss of p53

Tumour suppressor p53 or proto-oncogene MYC is frequently altered in squamous carcinomas, but this is insufficient to drive carcinogenesis. We have shown that overactivation of MYC or loss of p53 via DNA damage triggers an anti-oncogenic differentiation-mitosis checkpoint in human epidermal keratino...

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Detalles Bibliográficos
Autores principales: Molinuevo, R, Freije, A, de Pedro, I, Stoll, S W, Elder, J T, Gandarillas, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318665/
https://www.ncbi.nlm.nih.gov/pubmed/27452522
http://dx.doi.org/10.1038/onc.2016.262

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