The Snail repressor recruits EZH2 to specific genomic sites through the enrollment of the lncRNA HOTAIR in epithelial-to-mesenchymal transition

The transcription factor Snail is a master regulator of cellular identity and epithelial-to-mesenchymal transition (EMT) directly repressing a broad repertoire of epithelial genes. How chromatin modifiers instrumental to its activity are recruited to Snail-specific binding sites is unclear. Here we...

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Detalles Bibliográficos
Autores principales: Battistelli, C, Cicchini, C, Santangelo, L, Tramontano, A, Grassi, L, Gonzalez, F J, de Nonno, V, Grassi, G, Amicone, L, Tripodi, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318668/
https://www.ncbi.nlm.nih.gov/pubmed/27452518
http://dx.doi.org/10.1038/onc.2016.260

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