Citron Kinase Deficiency Leads to Chromosomal Instability and TP53-Sensitive Microcephaly

Mutations in citron (CIT), leading to loss or inactivation of the citron kinase protein (CITK), cause primary microcephaly in humans and rodents, associated with cytokinesis failure and apoptosis in neural progenitors. We show that CITK loss induces DNA damage accumulation and chromosomal instabilit...

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Detalles Bibliográficos
Autores principales: Bianchi, Federico Tommaso, Tocco, Chiara, Pallavicini, Gianmarco, Liu, Yifan, Vernì, Fiammetta, Merigliano, Chiara, Bonaccorsi, Silvia, El-Assawy, Nadia, Priano, Lorenzo, Gai, Marta, Berto, Gaia Elena, Chiotto, Alessandra Maria Adelaide, Sgrò, Francesco, Caramello, Alessia, Tasca, Laura, Ala, Ugo, Neri, Francesco, Oliviero, Salvatore, Mauro, Alessandro, Geley, Stephan, Gatti, Maurizio, Di Cunto, Ferdinando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318669/
https://www.ncbi.nlm.nih.gov/pubmed/28199840
http://dx.doi.org/10.1016/j.celrep.2017.01.054

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318669/
https://www.ncbi.nlm.nih.gov/pubmed/28199840
http://dx.doi.org/10.1016/j.celrep.2017.01.054

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