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Role of ATP as a Key Signaling Molecule Mediating Radiation-Induced Biological Effects

Adenosine triphosphate (ATP) serves as a signaling molecule for adaptive responses to a variety of cytotoxic agents and plays an important role in mediating the radiation stress-induced responses that serve to mitigate or repair the injurious effects of γ radiation on the body. Indeed, low doses of...

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Autores principales: Kojima, Shuji, Ohshima, Yasuhiro, Nakatsukasa, Hiroko, Tsukimoto, Mitsutoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318813/
https://www.ncbi.nlm.nih.gov/pubmed/28250717
http://dx.doi.org/10.1177/1559325817690638
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author Kojima, Shuji
Ohshima, Yasuhiro
Nakatsukasa, Hiroko
Tsukimoto, Mitsutoshi
author_facet Kojima, Shuji
Ohshima, Yasuhiro
Nakatsukasa, Hiroko
Tsukimoto, Mitsutoshi
author_sort Kojima, Shuji
collection PubMed
description Adenosine triphosphate (ATP) serves as a signaling molecule for adaptive responses to a variety of cytotoxic agents and plays an important role in mediating the radiation stress-induced responses that serve to mitigate or repair the injurious effects of γ radiation on the body. Indeed, low doses of radiation may have a net beneficial effect by activating a variety of protective mechanisms, including antitumor immune responses. On the other hand, ATP signaling may be involved in the radiation resistance of cancer cells. Here, focusing on our previous work, we review the evidence that low-dose γ irradiation (0.25-0.5 Gy) induces release of extracellular ATP, and that the released ATP mediates multiple radiation-induced responses, including increased intracellular antioxidant synthesis, cell-mediated immune responses, induction of DNA damage repair systems, and differentiation of regulatory T cells.
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spelling pubmed-53188132017-03-01 Role of ATP as a Key Signaling Molecule Mediating Radiation-Induced Biological Effects Kojima, Shuji Ohshima, Yasuhiro Nakatsukasa, Hiroko Tsukimoto, Mitsutoshi Dose Response Original Article Adenosine triphosphate (ATP) serves as a signaling molecule for adaptive responses to a variety of cytotoxic agents and plays an important role in mediating the radiation stress-induced responses that serve to mitigate or repair the injurious effects of γ radiation on the body. Indeed, low doses of radiation may have a net beneficial effect by activating a variety of protective mechanisms, including antitumor immune responses. On the other hand, ATP signaling may be involved in the radiation resistance of cancer cells. Here, focusing on our previous work, we review the evidence that low-dose γ irradiation (0.25-0.5 Gy) induces release of extracellular ATP, and that the released ATP mediates multiple radiation-induced responses, including increased intracellular antioxidant synthesis, cell-mediated immune responses, induction of DNA damage repair systems, and differentiation of regulatory T cells. SAGE Publications 2017-02-15 /pmc/articles/PMC5318813/ /pubmed/28250717 http://dx.doi.org/10.1177/1559325817690638 Text en © The Author(s) 2017 http://creativecommons.org/licenses/by-nc/3.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Article
Kojima, Shuji
Ohshima, Yasuhiro
Nakatsukasa, Hiroko
Tsukimoto, Mitsutoshi
Role of ATP as a Key Signaling Molecule Mediating Radiation-Induced Biological Effects
title Role of ATP as a Key Signaling Molecule Mediating Radiation-Induced Biological Effects
title_full Role of ATP as a Key Signaling Molecule Mediating Radiation-Induced Biological Effects
title_fullStr Role of ATP as a Key Signaling Molecule Mediating Radiation-Induced Biological Effects
title_full_unstemmed Role of ATP as a Key Signaling Molecule Mediating Radiation-Induced Biological Effects
title_short Role of ATP as a Key Signaling Molecule Mediating Radiation-Induced Biological Effects
title_sort role of atp as a key signaling molecule mediating radiation-induced biological effects
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318813/
https://www.ncbi.nlm.nih.gov/pubmed/28250717
http://dx.doi.org/10.1177/1559325817690638
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