Cbx3/HP1γ deficiency confers enhanced tumor-killing capacity on CD8(+) T cells

Cbx3/HP1γ is a histone reader whose function in the immune system is not completely understood. Here, we demonstrate that in CD8(+) T cells, Cbx3/HP1γ insufficiency leads to chromatin remodeling accompanied by enhanced Prf1, Gzmb and Ifng expression. In tumors obtained from Cbx3/HP1γ-insufficient mi...

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Detalles Bibliográficos
Autores principales: Sun, Michael, Ha, Ngoc, Pham, Duc-Hung, Frederick, Megan, Sharma, Bandana, Naruse, Chie, Asano, Masahide, Pipkin, Matthew E., George, Rani E., Thai, To-Ha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318867/
https://www.ncbi.nlm.nih.gov/pubmed/28220815
http://dx.doi.org/10.1038/srep42888

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318867/
https://www.ncbi.nlm.nih.gov/pubmed/28220815
http://dx.doi.org/10.1038/srep42888

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