Engineering Botulinum Neurotoxin C1 as a Molecular Vehicle for Intra-Neuronal Drug Delivery

Botulinum neurotoxin (BoNT) binds to and internalizes its light chain into presynaptic compartments with exquisite specificity. While the native toxin is extremely lethal, bioengineering of BoNT has the potential to eliminate toxicity without disrupting neuron-specific targeting, thereby creating a...

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Detalles Bibliográficos
Autores principales: Vazquez-Cintron, Edwin J., Beske, Phillip H., Tenezaca, Luis, Tran, Bao Q., Oyler, Jonathan M., Glotfelty, Elliot J., Angeles, Christopher A., Syngkon, Aurelia, Mukherjee, Jean, Kalb, Suzanne R., Band, Philip A., McNutt, Patrick M., Shoemaker, Charles B., Ichtchenko, Konstantin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318933/
https://www.ncbi.nlm.nih.gov/pubmed/28220863
http://dx.doi.org/10.1038/srep42923

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