PTEN status is a crucial determinant of the functional outcome of combined MEK and mTOR inhibition in cancer

Combined MAPK/PI3K pathway inhibition represents an attractive, albeit toxic, therapeutic strategy in oncology. Since PTEN lies at the intersection of these two pathways, we investigated whether PTEN status determines the functional response to combined pathway inhibition. PTEN (gene, mRNA, and prot...

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Detalles Bibliográficos
Autores principales: Milella, Michele, Falcone, Italia, Conciatori, Fabiana, Matteoni, Silvia, Sacconi, Andrea, De Luca, Teresa, Bazzichetto, Chiara, Corbo, Vincenzo, Simbolo, Michele, Sperduti, Isabella, Benfante, Antonina, Del Curatolo, Anais, Cesta Incani, Ursula, Malusa, Federico, Eramo, Adriana, Sette, Giovanni, Scarpa, Aldo, Konopleva, Marina, Andreeff, Michael, McCubrey, James Andrew, Blandino, Giovanni, Todaro, Matilde, Stassi, Giorgio, De Maria, Ruggero, Cognetti, Francesco, Del Bufalo, Donatella, Ciuffreda, Ludovica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318947/
https://www.ncbi.nlm.nih.gov/pubmed/28220839
http://dx.doi.org/10.1038/srep43013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318947/
https://www.ncbi.nlm.nih.gov/pubmed/28220839
http://dx.doi.org/10.1038/srep43013

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