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Post translational modification of Parkin

ABSTRACT: Mutations in the gene encoding for the E3 ubiquitin ligase Parkin are associated to a rare form of familiar autosomal recessive Parkinsonism. Despite decades of research on the Parkin protein, whose structure has been recently solved, little is known about the specific signalling pathways...

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Autores principales: Chakraborty, Joy, Basso, Valentina, Ziviani, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319146/
https://www.ncbi.nlm.nih.gov/pubmed/28222786
http://dx.doi.org/10.1186/s13062-017-0176-3
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author Chakraborty, Joy
Basso, Valentina
Ziviani, Elena
author_facet Chakraborty, Joy
Basso, Valentina
Ziviani, Elena
author_sort Chakraborty, Joy
collection PubMed
description ABSTRACT: Mutations in the gene encoding for the E3 ubiquitin ligase Parkin are associated to a rare form of familiar autosomal recessive Parkinsonism. Despite decades of research on the Parkin protein, whose structure has been recently solved, little is known about the specific signalling pathways that lead to Parkin activation. Parkin activity spans from mitochondria quality control to tumor suppression and stress protection; it is thus tempting to hypothesize that the broad impact of Parkin on cellular physiology might be the result of different post translational modifications that can be controlled by balanced opposing events. Sequence alignment of Parkin from different species indicates high homology between domains across Parkin orthologs and identifies highly conserved amino acid residues that, if modified, impinge on Parkin functions. In this review, we summarize findings on post translational modifications that have been shown to affect Parkin activity and stability. REVIEWERS: This article was reviewed by Prof. Dr. Konstanze F. Winklhofer and by Prof. Thomas Simmen. Both reviewers have been nominated by Professor Luca Pellegrini.
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spelling pubmed-53191462017-02-24 Post translational modification of Parkin Chakraborty, Joy Basso, Valentina Ziviani, Elena Biol Direct Review ABSTRACT: Mutations in the gene encoding for the E3 ubiquitin ligase Parkin are associated to a rare form of familiar autosomal recessive Parkinsonism. Despite decades of research on the Parkin protein, whose structure has been recently solved, little is known about the specific signalling pathways that lead to Parkin activation. Parkin activity spans from mitochondria quality control to tumor suppression and stress protection; it is thus tempting to hypothesize that the broad impact of Parkin on cellular physiology might be the result of different post translational modifications that can be controlled by balanced opposing events. Sequence alignment of Parkin from different species indicates high homology between domains across Parkin orthologs and identifies highly conserved amino acid residues that, if modified, impinge on Parkin functions. In this review, we summarize findings on post translational modifications that have been shown to affect Parkin activity and stability. REVIEWERS: This article was reviewed by Prof. Dr. Konstanze F. Winklhofer and by Prof. Thomas Simmen. Both reviewers have been nominated by Professor Luca Pellegrini. BioMed Central 2017-02-21 /pmc/articles/PMC5319146/ /pubmed/28222786 http://dx.doi.org/10.1186/s13062-017-0176-3 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Chakraborty, Joy
Basso, Valentina
Ziviani, Elena
Post translational modification of Parkin
title Post translational modification of Parkin
title_full Post translational modification of Parkin
title_fullStr Post translational modification of Parkin
title_full_unstemmed Post translational modification of Parkin
title_short Post translational modification of Parkin
title_sort post translational modification of parkin
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319146/
https://www.ncbi.nlm.nih.gov/pubmed/28222786
http://dx.doi.org/10.1186/s13062-017-0176-3
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