CCR7(+) selected gene-modified T cells maintain a central memory phenotype and display enhanced persistence in peripheral blood in vivo

BACKGROUND: Adoptive T cell immunotherapy (ATCT) for cancer entails infusing patients with T cells that recognise and destroy tumour cells. Efficient engraftment of T cells and persistence in the circulation correlate with favourable clinical outcomes. T cells of early differentiation possess an inc...

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Detalles Bibliográficos
Autores principales: Kueberuwa, Gray, Gornall, Hannah, Alcantar-Orozco, Erik Marcelo, Bouvier, Deborah, Kapacee, Zainul Abedin, Hawkins, Robert Edward, Gilham, David Edward
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319186/
https://www.ncbi.nlm.nih.gov/pubmed/28239467
http://dx.doi.org/10.1186/s40425-017-0216-7

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