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β-trace protein is highly removed during haemodialysis with high-flux and super high-flux membranes

BACKGROUND: Serum β-trace protein (βTP, MW 23–29 kDa) is a marker of GFR impairment in renal patients. Recent papers propose to predict residual renal function (RRF) in maintenance haemodialysis (MHD) patients from serum concentrations of βTP and other small proteins, avoiding the collection of urin...

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Autores principales: Donadio, Carlo, Tognotti, Danika, Caponi, Laura, Paolicchi, Aldo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319187/
https://www.ncbi.nlm.nih.gov/pubmed/28219328
http://dx.doi.org/10.1186/s12882-017-0489-6
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author Donadio, Carlo
Tognotti, Danika
Caponi, Laura
Paolicchi, Aldo
author_facet Donadio, Carlo
Tognotti, Danika
Caponi, Laura
Paolicchi, Aldo
author_sort Donadio, Carlo
collection PubMed
description BACKGROUND: Serum β-trace protein (βTP, MW 23–29 kDa) is a marker of GFR impairment in renal patients. Recent papers propose to predict residual renal function (RRF) in maintenance haemodialysis (MHD) patients from serum concentrations of βTP and other small proteins, avoiding the collection of urine. Few data are available on the removal of βTP in patients treated with dialysis membranes with different flux characteristics. The aim of this study was to evaluate the effects of haemodialysis with low-flux, high-flux and super high-flux membranes on serum concentrations of ßTP in MHD patients with null RRF. METHODS: Serum ßTP concentrations were measured before and after the first dialysis of the week in 51 MDH patients treated by low-flux (n = 24), high-flux (n = 17), or super high-flux (n = 10) membranes. The removal of β2-microglobulin (β2M, MW 11.8), cystatin C (Cys, MW 13.3), urea and creatinine was also analyzed. RESULTS: Low-flux membranes did not remove βTP, β2M and Cys whose concentration increased at the end of dialysis. High-flux membrane removed more efficiently β2M and Cys than ßTP. Super high-flux membrane had the highest efficiency to remove ßTP: mean reduction ratio (RR) 53.4%, similar to β2M (59.5%), and Cys (62.0%). CONCLUSIONS: In conclusion, the plasma clearance of small proteins and particularly of βTP is dependent from the permeability of the dialysis membranes Therefore, the reliability of the formulas proposed to predict RRF from serum βTP and other LMWP may be affected by the different permeability of the dialysis membranes.
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spelling pubmed-53191872017-02-24 β-trace protein is highly removed during haemodialysis with high-flux and super high-flux membranes Donadio, Carlo Tognotti, Danika Caponi, Laura Paolicchi, Aldo BMC Nephrol Research Article BACKGROUND: Serum β-trace protein (βTP, MW 23–29 kDa) is a marker of GFR impairment in renal patients. Recent papers propose to predict residual renal function (RRF) in maintenance haemodialysis (MHD) patients from serum concentrations of βTP and other small proteins, avoiding the collection of urine. Few data are available on the removal of βTP in patients treated with dialysis membranes with different flux characteristics. The aim of this study was to evaluate the effects of haemodialysis with low-flux, high-flux and super high-flux membranes on serum concentrations of ßTP in MHD patients with null RRF. METHODS: Serum ßTP concentrations were measured before and after the first dialysis of the week in 51 MDH patients treated by low-flux (n = 24), high-flux (n = 17), or super high-flux (n = 10) membranes. The removal of β2-microglobulin (β2M, MW 11.8), cystatin C (Cys, MW 13.3), urea and creatinine was also analyzed. RESULTS: Low-flux membranes did not remove βTP, β2M and Cys whose concentration increased at the end of dialysis. High-flux membrane removed more efficiently β2M and Cys than ßTP. Super high-flux membrane had the highest efficiency to remove ßTP: mean reduction ratio (RR) 53.4%, similar to β2M (59.5%), and Cys (62.0%). CONCLUSIONS: In conclusion, the plasma clearance of small proteins and particularly of βTP is dependent from the permeability of the dialysis membranes Therefore, the reliability of the formulas proposed to predict RRF from serum βTP and other LMWP may be affected by the different permeability of the dialysis membranes. BioMed Central 2017-02-20 /pmc/articles/PMC5319187/ /pubmed/28219328 http://dx.doi.org/10.1186/s12882-017-0489-6 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Donadio, Carlo
Tognotti, Danika
Caponi, Laura
Paolicchi, Aldo
β-trace protein is highly removed during haemodialysis with high-flux and super high-flux membranes
title β-trace protein is highly removed during haemodialysis with high-flux and super high-flux membranes
title_full β-trace protein is highly removed during haemodialysis with high-flux and super high-flux membranes
title_fullStr β-trace protein is highly removed during haemodialysis with high-flux and super high-flux membranes
title_full_unstemmed β-trace protein is highly removed during haemodialysis with high-flux and super high-flux membranes
title_short β-trace protein is highly removed during haemodialysis with high-flux and super high-flux membranes
title_sort β-trace protein is highly removed during haemodialysis with high-flux and super high-flux membranes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319187/
https://www.ncbi.nlm.nih.gov/pubmed/28219328
http://dx.doi.org/10.1186/s12882-017-0489-6
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