Breviscapine reduces neuronal injury caused by traumatic brain injury insult: partly associated with suppression of interleukin-6 expression

Breviscapine, extracted from the herb Erigeron breviscapus, is widely used for the treatment of cardiovascular diseases, cerebral infarct, and stroke, but its mechanism of action remains unclear. This study established a rat model of traumatic brain injury induced by controlled cortical impact, and...

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Autores principales: Jiang, Ling, Hu, Yue, He, Xiang, Lv, Qiang, Wang, Ting-hua, Xia, Qing-jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319248/
https://www.ncbi.nlm.nih.gov/pubmed/28250753
http://dx.doi.org/10.4103/1673-5374.198990
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author Jiang, Ling
Hu, Yue
He, Xiang
Lv, Qiang
Wang, Ting-hua
Xia, Qing-jie
author_facet Jiang, Ling
Hu, Yue
He, Xiang
Lv, Qiang
Wang, Ting-hua
Xia, Qing-jie
author_sort Jiang, Ling
collection PubMed
description Breviscapine, extracted from the herb Erigeron breviscapus, is widely used for the treatment of cardiovascular diseases, cerebral infarct, and stroke, but its mechanism of action remains unclear. This study established a rat model of traumatic brain injury induced by controlled cortical impact, and injected 75 μg breviscapine via the right lateral ventricle. We found that breviscapine significantly improved neurobehavioral dysfunction at 6 and 9 days after injection. Meanwhile, interleukin-6 expression was markedly down-regulated following breviscapine treatment. Our results suggest that breviscapine is effective in promoting neurological behavior after traumatic brain injury and the underlying molecular mechanism may be associated with the suppression of interleukin-6.
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spelling pubmed-53192482017-03-01 Breviscapine reduces neuronal injury caused by traumatic brain injury insult: partly associated with suppression of interleukin-6 expression Jiang, Ling Hu, Yue He, Xiang Lv, Qiang Wang, Ting-hua Xia, Qing-jie Neural Regen Res Research Article Breviscapine, extracted from the herb Erigeron breviscapus, is widely used for the treatment of cardiovascular diseases, cerebral infarct, and stroke, but its mechanism of action remains unclear. This study established a rat model of traumatic brain injury induced by controlled cortical impact, and injected 75 μg breviscapine via the right lateral ventricle. We found that breviscapine significantly improved neurobehavioral dysfunction at 6 and 9 days after injection. Meanwhile, interleukin-6 expression was markedly down-regulated following breviscapine treatment. Our results suggest that breviscapine is effective in promoting neurological behavior after traumatic brain injury and the underlying molecular mechanism may be associated with the suppression of interleukin-6. Medknow Publications & Media Pvt Ltd 2017-01 /pmc/articles/PMC5319248/ /pubmed/28250753 http://dx.doi.org/10.4103/1673-5374.198990 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Research Article
Jiang, Ling
Hu, Yue
He, Xiang
Lv, Qiang
Wang, Ting-hua
Xia, Qing-jie
Breviscapine reduces neuronal injury caused by traumatic brain injury insult: partly associated with suppression of interleukin-6 expression
title Breviscapine reduces neuronal injury caused by traumatic brain injury insult: partly associated with suppression of interleukin-6 expression
title_full Breviscapine reduces neuronal injury caused by traumatic brain injury insult: partly associated with suppression of interleukin-6 expression
title_fullStr Breviscapine reduces neuronal injury caused by traumatic brain injury insult: partly associated with suppression of interleukin-6 expression
title_full_unstemmed Breviscapine reduces neuronal injury caused by traumatic brain injury insult: partly associated with suppression of interleukin-6 expression
title_short Breviscapine reduces neuronal injury caused by traumatic brain injury insult: partly associated with suppression of interleukin-6 expression
title_sort breviscapine reduces neuronal injury caused by traumatic brain injury insult: partly associated with suppression of interleukin-6 expression
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319248/
https://www.ncbi.nlm.nih.gov/pubmed/28250753
http://dx.doi.org/10.4103/1673-5374.198990
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