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Hepatoprotective effect of Zataria Multiflora Boisson cisplatin-induced oxidative stress in male rat

Background: This research aimed to evaluate the protective effects of methanolic extract of Zataria Multiflora Boiss (Z. Multiflora) against hepatic damage induced by cisplatin in male Wistar rats. Methods: Hepatotoxicity was induced in Wistar male rats by a single intraperitoneal administration of...

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Autores principales: Ahmadipour, A, Sharififar, F, Nakhaipour, F, Samanian, M, Karami-Mohajeri, S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Carol Davila University Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319274/
https://www.ncbi.nlm.nih.gov/pubmed/28316744
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author Ahmadipour, A
Sharififar, F
Nakhaipour, F
Samanian, M
Karami-Mohajeri, S
author_facet Ahmadipour, A
Sharififar, F
Nakhaipour, F
Samanian, M
Karami-Mohajeri, S
author_sort Ahmadipour, A
collection PubMed
description Background: This research aimed to evaluate the protective effects of methanolic extract of Zataria Multiflora Boiss (Z. Multiflora) against hepatic damage induced by cisplatin in male Wistar rats. Methods: Hepatotoxicity was induced in Wistar male rats by a single intraperitoneal administration of cisplatin, 7 g/ kg body weight. A methanolic extract of Z. Multiflora was administered orally at doses of 50 mg/ kg, 100 mg/ kg, 200 mg/ kg and 400 mg/ kg body weight daily for seven days after being cisplatin-induced. The study included the histopathological examination of the liver sections. The activity of aspartate transaminase (AST), alanine transaminase (ALT), and alkaline phosphatase (ALP) were evaluated as markers of liver damage. The superoxide dismutase (SOD), the activity of Catalase (CAT), and glutathione peroxidase (GSH-Px) and malondialdehyde (MDA) and nitric oxide (NO) content in serum were measured as an oxidative stress factor. Results: The results showed that rat treated with cisplatin resulted in a significant increase in serum activity, AST, ALT and ALP in treated mice. Management with Z. Multiflora reduced the business of these enzymes to nearly normal levels. In parallel with these changes, this extract reduced cisplatin-induced oxidative stress by inhibiting lipid peroxidation and protein carbonylation, and restoring the antioxidant enzyme (SOD, CAT, and GSH-Px) and elevation of the glutathione level. Conclusion: Biochemical and histological observations showed the hepatoprotective effect was found in a dose-dependent manner in Z. Multiflora methanolic extract. This protective effect can be attributed to the antioxidant compounds.
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spelling pubmed-53192742017-03-17 Hepatoprotective effect of Zataria Multiflora Boisson cisplatin-induced oxidative stress in male rat Ahmadipour, A Sharififar, F Nakhaipour, F Samanian, M Karami-Mohajeri, S J Med Life Case Presentations Background: This research aimed to evaluate the protective effects of methanolic extract of Zataria Multiflora Boiss (Z. Multiflora) against hepatic damage induced by cisplatin in male Wistar rats. Methods: Hepatotoxicity was induced in Wistar male rats by a single intraperitoneal administration of cisplatin, 7 g/ kg body weight. A methanolic extract of Z. Multiflora was administered orally at doses of 50 mg/ kg, 100 mg/ kg, 200 mg/ kg and 400 mg/ kg body weight daily for seven days after being cisplatin-induced. The study included the histopathological examination of the liver sections. The activity of aspartate transaminase (AST), alanine transaminase (ALT), and alkaline phosphatase (ALP) were evaluated as markers of liver damage. The superoxide dismutase (SOD), the activity of Catalase (CAT), and glutathione peroxidase (GSH-Px) and malondialdehyde (MDA) and nitric oxide (NO) content in serum were measured as an oxidative stress factor. Results: The results showed that rat treated with cisplatin resulted in a significant increase in serum activity, AST, ALT and ALP in treated mice. Management with Z. Multiflora reduced the business of these enzymes to nearly normal levels. In parallel with these changes, this extract reduced cisplatin-induced oxidative stress by inhibiting lipid peroxidation and protein carbonylation, and restoring the antioxidant enzyme (SOD, CAT, and GSH-Px) and elevation of the glutathione level. Conclusion: Biochemical and histological observations showed the hepatoprotective effect was found in a dose-dependent manner in Z. Multiflora methanolic extract. This protective effect can be attributed to the antioxidant compounds. Carol Davila University Press 2015 /pmc/articles/PMC5319274/ /pubmed/28316744 Text en ©Carol Davila University Press http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Presentations
Ahmadipour, A
Sharififar, F
Nakhaipour, F
Samanian, M
Karami-Mohajeri, S
Hepatoprotective effect of Zataria Multiflora Boisson cisplatin-induced oxidative stress in male rat
title Hepatoprotective effect of Zataria Multiflora Boisson cisplatin-induced oxidative stress in male rat
title_full Hepatoprotective effect of Zataria Multiflora Boisson cisplatin-induced oxidative stress in male rat
title_fullStr Hepatoprotective effect of Zataria Multiflora Boisson cisplatin-induced oxidative stress in male rat
title_full_unstemmed Hepatoprotective effect of Zataria Multiflora Boisson cisplatin-induced oxidative stress in male rat
title_short Hepatoprotective effect of Zataria Multiflora Boisson cisplatin-induced oxidative stress in male rat
title_sort hepatoprotective effect of zataria multiflora boisson cisplatin-induced oxidative stress in male rat
topic Case Presentations
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319274/
https://www.ncbi.nlm.nih.gov/pubmed/28316744
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