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Tuberculosis associated factors caused by Mycobacterium tuberculosis of the RD(Rio) genotype

BACKGROUND: Tuberculosis (TB) continues to be a disease that affects many countries around the world, including Brazil. Recently, a subtype of Latin American-Mediterranean family strain was identified and characterised by RD(Rio). The strain has been associated with different characteristics of the...

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Autores principales: Moraes, Eloise Brasil, Slompo, Letícia, Finardi, Amanda Juliane, da Silveira, Heloisa Paro Pedro, Ruiz, Luciana, Gomes, Harrison Magdinier, Richini, Virginia Bodelão, Suffys, Philip, Fortaleza, Carlos Magno Castelo Branco, Cavalcanti, Ricardo, Baptista, Ida Maria Foschiani Dias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto Oswaldo Cruz, Ministério da Saúde 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319367/
https://www.ncbi.nlm.nih.gov/pubmed/28225901
http://dx.doi.org/10.1590/0074-02760160347
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author Moraes, Eloise Brasil
Slompo, Letícia
Finardi, Amanda Juliane
da Silveira, Heloisa Paro Pedro
Ruiz, Luciana
Gomes, Harrison Magdinier
Richini, Virginia Bodelão
Suffys, Philip
Fortaleza, Carlos Magno Castelo Branco
Cavalcanti, Ricardo
Baptista, Ida Maria Foschiani Dias
author_facet Moraes, Eloise Brasil
Slompo, Letícia
Finardi, Amanda Juliane
da Silveira, Heloisa Paro Pedro
Ruiz, Luciana
Gomes, Harrison Magdinier
Richini, Virginia Bodelão
Suffys, Philip
Fortaleza, Carlos Magno Castelo Branco
Cavalcanti, Ricardo
Baptista, Ida Maria Foschiani Dias
author_sort Moraes, Eloise Brasil
collection PubMed
description BACKGROUND: Tuberculosis (TB) continues to be a disease that affects many countries around the world, including Brazil. Recently, a subtype of Latin American-Mediterranean family strain was identified and characterised by RD(Rio). The strain has been associated with different characteristics of the disease. OBJECTIVES: In the present study we investigated the association of epidemiological, clinical, radiological and bacteriological variables with pulmonary tuberculosis caused by RD(Rio) Mycobacterium tuberculosis strain in large regions of São Paulo. METHODS: We conducted a cross-sectional study in 530 patients with pulmonary tuberculosis, diagnosed using sputum culture, from two regions of the São Paulo state in Brazil. The samples were brought to São Paulo reference laboratories for epidemiological, clinical, radiological and bacteriological analyses, and the data were obtained from a TB notification system. RD(Rio) genotyping and Spoligotyping of the samples were performed. For the analysis of the categorical variables we used the chi-square test or the Fisher’s exact test, and for the continuous variables, the Mann-Whitney test. In addition, a logistic regression was used for multivariate analysis. Differences with p < 0.05 were considered significant. FINDINGS THE RDRIO: deletion was identified in 152 (28.7%) samples. In the univariate analysis, both the age groups above 25 years and alcohol consumption were associated with the RD(Rio) deletion. The multivariate analysis confirmed the association of the RD(Rio) deletion with the age groups: 25-35 years old [OR: 2.28 (1.02-5.07; p = 0.04)] and 36-60 years old (OR: 2.36 (1.11-5.05); p = 0.03], and also with alcohol consumption [OR: 1.63 (1.05-2.54); p = 0,03]. MAIN CONCLUSIONS: In this study, we identified new factors associated with the M. tuberculosis of the RD(Rio) deletion strains infection.
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spelling pubmed-53193672017-03-01 Tuberculosis associated factors caused by Mycobacterium tuberculosis of the RD(Rio) genotype Moraes, Eloise Brasil Slompo, Letícia Finardi, Amanda Juliane da Silveira, Heloisa Paro Pedro Ruiz, Luciana Gomes, Harrison Magdinier Richini, Virginia Bodelão Suffys, Philip Fortaleza, Carlos Magno Castelo Branco Cavalcanti, Ricardo Baptista, Ida Maria Foschiani Dias Mem Inst Oswaldo Cruz Articles BACKGROUND: Tuberculosis (TB) continues to be a disease that affects many countries around the world, including Brazil. Recently, a subtype of Latin American-Mediterranean family strain was identified and characterised by RD(Rio). The strain has been associated with different characteristics of the disease. OBJECTIVES: In the present study we investigated the association of epidemiological, clinical, radiological and bacteriological variables with pulmonary tuberculosis caused by RD(Rio) Mycobacterium tuberculosis strain in large regions of São Paulo. METHODS: We conducted a cross-sectional study in 530 patients with pulmonary tuberculosis, diagnosed using sputum culture, from two regions of the São Paulo state in Brazil. The samples were brought to São Paulo reference laboratories for epidemiological, clinical, radiological and bacteriological analyses, and the data were obtained from a TB notification system. RD(Rio) genotyping and Spoligotyping of the samples were performed. For the analysis of the categorical variables we used the chi-square test or the Fisher’s exact test, and for the continuous variables, the Mann-Whitney test. In addition, a logistic regression was used for multivariate analysis. Differences with p < 0.05 were considered significant. FINDINGS THE RDRIO: deletion was identified in 152 (28.7%) samples. In the univariate analysis, both the age groups above 25 years and alcohol consumption were associated with the RD(Rio) deletion. The multivariate analysis confirmed the association of the RD(Rio) deletion with the age groups: 25-35 years old [OR: 2.28 (1.02-5.07; p = 0.04)] and 36-60 years old (OR: 2.36 (1.11-5.05); p = 0.03], and also with alcohol consumption [OR: 1.63 (1.05-2.54); p = 0,03]. MAIN CONCLUSIONS: In this study, we identified new factors associated with the M. tuberculosis of the RD(Rio) deletion strains infection. Instituto Oswaldo Cruz, Ministério da Saúde 2017-02-16 2017-03 /pmc/articles/PMC5319367/ /pubmed/28225901 http://dx.doi.org/10.1590/0074-02760160347 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Moraes, Eloise Brasil
Slompo, Letícia
Finardi, Amanda Juliane
da Silveira, Heloisa Paro Pedro
Ruiz, Luciana
Gomes, Harrison Magdinier
Richini, Virginia Bodelão
Suffys, Philip
Fortaleza, Carlos Magno Castelo Branco
Cavalcanti, Ricardo
Baptista, Ida Maria Foschiani Dias
Tuberculosis associated factors caused by Mycobacterium tuberculosis of the RD(Rio) genotype
title Tuberculosis associated factors caused by Mycobacterium tuberculosis of the RD(Rio) genotype
title_full Tuberculosis associated factors caused by Mycobacterium tuberculosis of the RD(Rio) genotype
title_fullStr Tuberculosis associated factors caused by Mycobacterium tuberculosis of the RD(Rio) genotype
title_full_unstemmed Tuberculosis associated factors caused by Mycobacterium tuberculosis of the RD(Rio) genotype
title_short Tuberculosis associated factors caused by Mycobacterium tuberculosis of the RD(Rio) genotype
title_sort tuberculosis associated factors caused by mycobacterium tuberculosis of the rd(rio) genotype
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319367/
https://www.ncbi.nlm.nih.gov/pubmed/28225901
http://dx.doi.org/10.1590/0074-02760160347
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