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Tuberculosis associated factors caused by Mycobacterium tuberculosis of the RD(Rio) genotype
BACKGROUND: Tuberculosis (TB) continues to be a disease that affects many countries around the world, including Brazil. Recently, a subtype of Latin American-Mediterranean family strain was identified and characterised by RD(Rio). The strain has been associated with different characteristics of the...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Instituto Oswaldo Cruz, Ministério da Saúde
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319367/ https://www.ncbi.nlm.nih.gov/pubmed/28225901 http://dx.doi.org/10.1590/0074-02760160347 |
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author | Moraes, Eloise Brasil Slompo, Letícia Finardi, Amanda Juliane da Silveira, Heloisa Paro Pedro Ruiz, Luciana Gomes, Harrison Magdinier Richini, Virginia Bodelão Suffys, Philip Fortaleza, Carlos Magno Castelo Branco Cavalcanti, Ricardo Baptista, Ida Maria Foschiani Dias |
author_facet | Moraes, Eloise Brasil Slompo, Letícia Finardi, Amanda Juliane da Silveira, Heloisa Paro Pedro Ruiz, Luciana Gomes, Harrison Magdinier Richini, Virginia Bodelão Suffys, Philip Fortaleza, Carlos Magno Castelo Branco Cavalcanti, Ricardo Baptista, Ida Maria Foschiani Dias |
author_sort | Moraes, Eloise Brasil |
collection | PubMed |
description | BACKGROUND: Tuberculosis (TB) continues to be a disease that affects many countries around the world, including Brazil. Recently, a subtype of Latin American-Mediterranean family strain was identified and characterised by RD(Rio). The strain has been associated with different characteristics of the disease. OBJECTIVES: In the present study we investigated the association of epidemiological, clinical, radiological and bacteriological variables with pulmonary tuberculosis caused by RD(Rio) Mycobacterium tuberculosis strain in large regions of São Paulo. METHODS: We conducted a cross-sectional study in 530 patients with pulmonary tuberculosis, diagnosed using sputum culture, from two regions of the São Paulo state in Brazil. The samples were brought to São Paulo reference laboratories for epidemiological, clinical, radiological and bacteriological analyses, and the data were obtained from a TB notification system. RD(Rio) genotyping and Spoligotyping of the samples were performed. For the analysis of the categorical variables we used the chi-square test or the Fisher’s exact test, and for the continuous variables, the Mann-Whitney test. In addition, a logistic regression was used for multivariate analysis. Differences with p < 0.05 were considered significant. FINDINGS THE RDRIO: deletion was identified in 152 (28.7%) samples. In the univariate analysis, both the age groups above 25 years and alcohol consumption were associated with the RD(Rio) deletion. The multivariate analysis confirmed the association of the RD(Rio) deletion with the age groups: 25-35 years old [OR: 2.28 (1.02-5.07; p = 0.04)] and 36-60 years old (OR: 2.36 (1.11-5.05); p = 0.03], and also with alcohol consumption [OR: 1.63 (1.05-2.54); p = 0,03]. MAIN CONCLUSIONS: In this study, we identified new factors associated with the M. tuberculosis of the RD(Rio) deletion strains infection. |
format | Online Article Text |
id | pubmed-5319367 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Instituto Oswaldo Cruz, Ministério da Saúde |
record_format | MEDLINE/PubMed |
spelling | pubmed-53193672017-03-01 Tuberculosis associated factors caused by Mycobacterium tuberculosis of the RD(Rio) genotype Moraes, Eloise Brasil Slompo, Letícia Finardi, Amanda Juliane da Silveira, Heloisa Paro Pedro Ruiz, Luciana Gomes, Harrison Magdinier Richini, Virginia Bodelão Suffys, Philip Fortaleza, Carlos Magno Castelo Branco Cavalcanti, Ricardo Baptista, Ida Maria Foschiani Dias Mem Inst Oswaldo Cruz Articles BACKGROUND: Tuberculosis (TB) continues to be a disease that affects many countries around the world, including Brazil. Recently, a subtype of Latin American-Mediterranean family strain was identified and characterised by RD(Rio). The strain has been associated with different characteristics of the disease. OBJECTIVES: In the present study we investigated the association of epidemiological, clinical, radiological and bacteriological variables with pulmonary tuberculosis caused by RD(Rio) Mycobacterium tuberculosis strain in large regions of São Paulo. METHODS: We conducted a cross-sectional study in 530 patients with pulmonary tuberculosis, diagnosed using sputum culture, from two regions of the São Paulo state in Brazil. The samples were brought to São Paulo reference laboratories for epidemiological, clinical, radiological and bacteriological analyses, and the data were obtained from a TB notification system. RD(Rio) genotyping and Spoligotyping of the samples were performed. For the analysis of the categorical variables we used the chi-square test or the Fisher’s exact test, and for the continuous variables, the Mann-Whitney test. In addition, a logistic regression was used for multivariate analysis. Differences with p < 0.05 were considered significant. FINDINGS THE RDRIO: deletion was identified in 152 (28.7%) samples. In the univariate analysis, both the age groups above 25 years and alcohol consumption were associated with the RD(Rio) deletion. The multivariate analysis confirmed the association of the RD(Rio) deletion with the age groups: 25-35 years old [OR: 2.28 (1.02-5.07; p = 0.04)] and 36-60 years old (OR: 2.36 (1.11-5.05); p = 0.03], and also with alcohol consumption [OR: 1.63 (1.05-2.54); p = 0,03]. MAIN CONCLUSIONS: In this study, we identified new factors associated with the M. tuberculosis of the RD(Rio) deletion strains infection. Instituto Oswaldo Cruz, Ministério da Saúde 2017-02-16 2017-03 /pmc/articles/PMC5319367/ /pubmed/28225901 http://dx.doi.org/10.1590/0074-02760160347 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Articles Moraes, Eloise Brasil Slompo, Letícia Finardi, Amanda Juliane da Silveira, Heloisa Paro Pedro Ruiz, Luciana Gomes, Harrison Magdinier Richini, Virginia Bodelão Suffys, Philip Fortaleza, Carlos Magno Castelo Branco Cavalcanti, Ricardo Baptista, Ida Maria Foschiani Dias Tuberculosis associated factors caused by Mycobacterium tuberculosis of the RD(Rio) genotype |
title | Tuberculosis associated factors caused by Mycobacterium tuberculosis of the RD(Rio) genotype |
title_full | Tuberculosis associated factors caused by Mycobacterium tuberculosis of the RD(Rio) genotype |
title_fullStr | Tuberculosis associated factors caused by Mycobacterium tuberculosis of the RD(Rio) genotype |
title_full_unstemmed | Tuberculosis associated factors caused by Mycobacterium tuberculosis of the RD(Rio) genotype |
title_short | Tuberculosis associated factors caused by Mycobacterium tuberculosis of the RD(Rio) genotype |
title_sort | tuberculosis associated factors caused by mycobacterium tuberculosis of the rd(rio) genotype |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319367/ https://www.ncbi.nlm.nih.gov/pubmed/28225901 http://dx.doi.org/10.1590/0074-02760160347 |
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