Identification, validation, and targeting of the mutant p53-PARP-MCM chromatin axis in triple negative breast cancer

Over 80% of triple negative breast cancers express mutant p53. Mutant p53 often gains oncogenic function suggesting that triple negative breast cancers may be driven by p53 protein type. To determine the chromatin targets of this gain-of-function mutant p53 we used inducible knockdown of endogenous...

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Detalles Bibliográficos
Autores principales: Qiu, Wei-Gang, Polotskaia, Alla, Xiao, Gu, Di, Lia, Zhao, Yuhan, Hu, Wenwei, Philip, John, Hendrickson, Ronald C., Bargonetti, Jill
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319483/
https://www.ncbi.nlm.nih.gov/pubmed/28232952
http://dx.doi.org/10.1038/s41523-016-0001-7

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