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Dexmedetomidine preconditioning may attenuate myocardial ischemia/reperfusion injury by down-regulating the HMGB1-TLR4-MyD88-NF-кB signaling pathway

AIMS: To investigate whether dexmedetomidine (DEX) preconditioning could alleviate the inflammation caused by myocardial ischemia/reperfusion (I/R) injury by reducing HMGB1-TLR4-MyD88-NF-кB signaling. METHODS: Seventy rats were randomly assigned into five groups: sham group, myocardial I/R group (I/...

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Detalles Bibliográficos
Autores principales:	Zhang, Jing-jing, Peng, Ke, Zhang, Juan, Meng, Xiao-wen, Ji, Fu-hai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319750/ https://www.ncbi.nlm.nih.gov/pubmed/28222157 http://dx.doi.org/10.1371/journal.pone.0172006

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