Oxidative stress-mediated NFκB phosphorylation upregulates p62/SQSTM1 and promotes retinal pigmented epithelial cell survival through increased autophagy

p62 is a scaffolding adaptor implicated in the clearance of protein aggregates by autophagy. Reactive oxygen species (ROS) can either stimulate or inhibit NFκB-mediated gene expression influencing cellular fate. We studied the effect of hydrogen peroxide (H(2)O(2))-mediated oxidative stress and NFκB...

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Detalles Bibliográficos
Autores principales: Song, Chunjuan, Mitter, Sayak K., Qi, Xiaoping, Beli, Eleni, Rao, Haripriya V., Ding, Jindong, Ip, Colin S., Gu, Hongmei, Akin, Debra, Dunn, William A., Bowes Rickman, Catherine, Lewin, Alfred S., Grant, Maria B., Boulton, Michael E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319799/
https://www.ncbi.nlm.nih.gov/pubmed/28222108
http://dx.doi.org/10.1371/journal.pone.0171940

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