A Comparative Phase I Study of Combination, Homologous Subtype-C DNA, MVA, and Env gp140 Protein/Adjuvant HIV Vaccines in Two Immunization Regimes

There remains an urgent need for a prophylactic HIV vaccine. We compared combined MVA and adjuvanted gp140 to sequential MVA/gp140 after DNA priming. We expected Env-specific CD4+ T-cells after DNA and MVA priming, and Env-binding antibodies in 100% individuals after boosting with gp140 and that com...

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Detalles Bibliográficos
Autores principales: Joseph, Sarah, Quinn, Killian, Greenwood, Aldona, Cope, Alethea V., McKay, Paul F., Hayes, Peter J., Kopycinski, Jakub T., Gilmour, Jill, Miller, Aleisha N., Geldmacher, Christof, Nadai, Yuka, Ahmed, Mohamed I. M., Montefiori, David C., Dally, Len, Bouliotis, George, Lewis, David J. M., Tatoud, Roger, Wagner, Ralf, Esteban, Mariano, Shattock, Robin J., McCormack, Sheena, Weber, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319954/
https://www.ncbi.nlm.nih.gov/pubmed/28275375
http://dx.doi.org/10.3389/fimmu.2017.00149

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