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Mutant Analysis Reveals Allosteric Regulation of ClpB Disaggregase

The members of the hexameric AAA+ disaggregase of E. coli and S. cerevisiae, ClpB, and Hsp104, cooperate with the Hsp70 chaperone system in the solubilization of aggregated proteins. Aggregate solubilization relies on a substrate threading activity of ClpB/Hsp104 fueled by ATP hydrolysis in both ATP...

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Detalles Bibliográficos
Autores principales:	Franke, Kamila B., Bukau, Bernd, Mogk, Axel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319980/ https://www.ncbi.nlm.nih.gov/pubmed/28275610 http://dx.doi.org/10.3389/fmolb.2017.00006

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