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Fecal occult blood testing for the prediction of small-bowel pathology detected by capsule endoscopy: a systematic review and meta-analysis
BACKGROUND: Fecal occult blood testing (FOBT) has been suggested as a potential screening tool for small-bowel capsule endoscopy (CE). We conducted a meta-analysis of studies correlating FOBT and CE findings to examine the predictive value of positive FOBT for CE findings. METHODS: PubMed and Embase...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hellenic Society of Gastroenterology
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320031/ https://www.ncbi.nlm.nih.gov/pubmed/28243039 http://dx.doi.org/10.20524/aog.2017.0122 |
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author | Yung, Diana E. Vijayan, Sanju Avni, Tomer Douglas, Sarah Kopylov, Uri Koulaouzidis, Anastasios |
author_facet | Yung, Diana E. Vijayan, Sanju Avni, Tomer Douglas, Sarah Kopylov, Uri Koulaouzidis, Anastasios |
author_sort | Yung, Diana E. |
collection | PubMed |
description | BACKGROUND: Fecal occult blood testing (FOBT) has been suggested as a potential screening tool for small-bowel capsule endoscopy (CE). We conducted a meta-analysis of studies correlating FOBT and CE findings to examine the predictive value of positive FOBT for CE findings. METHODS: PubMed and Embase search. Sensitivity, specificity and diagnostic odds ratios (DORs) were calculated. RESULTS: Six studies were identified. Four used fecal immunochemical testing (FIT), one used FIT and guaiac FOBT, one used hemoglobin/haptoglobin complex testing (Hb/Hpt). Five of the 6 studies were suitable for statistical analysis. For all positive FOBT, sensitivity for small-bowel findings was 0.60 (95%CI 0.50-0.69), specificity was 0.72 (95%CI 0.52-0.86), and DOR was 3.96 (95%CI 1.50-10.4). For the 4 studies using only FIT, sensitivity was 0.48 (95%CI 0.36-0.61), specificity was 0.60 (95%CI 0.42-0.76), and DOR was 1.41 (95%CI 0.72-2.75). CONCLUSIONS: Although a number of modalities have been suggested for screening small-bowel CE referrals, none of them, including FOBT, offer a comprehensive solution. Further work is required to refine screening methods for small-bowel CE referrals. |
format | Online Article Text |
id | pubmed-5320031 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hellenic Society of Gastroenterology |
record_format | MEDLINE/PubMed |
spelling | pubmed-53200312017-02-27 Fecal occult blood testing for the prediction of small-bowel pathology detected by capsule endoscopy: a systematic review and meta-analysis Yung, Diana E. Vijayan, Sanju Avni, Tomer Douglas, Sarah Kopylov, Uri Koulaouzidis, Anastasios Ann Gastroenterol Original Article BACKGROUND: Fecal occult blood testing (FOBT) has been suggested as a potential screening tool for small-bowel capsule endoscopy (CE). We conducted a meta-analysis of studies correlating FOBT and CE findings to examine the predictive value of positive FOBT for CE findings. METHODS: PubMed and Embase search. Sensitivity, specificity and diagnostic odds ratios (DORs) were calculated. RESULTS: Six studies were identified. Four used fecal immunochemical testing (FIT), one used FIT and guaiac FOBT, one used hemoglobin/haptoglobin complex testing (Hb/Hpt). Five of the 6 studies were suitable for statistical analysis. For all positive FOBT, sensitivity for small-bowel findings was 0.60 (95%CI 0.50-0.69), specificity was 0.72 (95%CI 0.52-0.86), and DOR was 3.96 (95%CI 1.50-10.4). For the 4 studies using only FIT, sensitivity was 0.48 (95%CI 0.36-0.61), specificity was 0.60 (95%CI 0.42-0.76), and DOR was 1.41 (95%CI 0.72-2.75). CONCLUSIONS: Although a number of modalities have been suggested for screening small-bowel CE referrals, none of them, including FOBT, offer a comprehensive solution. Further work is required to refine screening methods for small-bowel CE referrals. Hellenic Society of Gastroenterology 2017 2017-01-05 /pmc/articles/PMC5320031/ /pubmed/28243039 http://dx.doi.org/10.20524/aog.2017.0122 Text en Copyright: © Hellenic Society of Gastroenterology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Yung, Diana E. Vijayan, Sanju Avni, Tomer Douglas, Sarah Kopylov, Uri Koulaouzidis, Anastasios Fecal occult blood testing for the prediction of small-bowel pathology detected by capsule endoscopy: a systematic review and meta-analysis |
title | Fecal occult blood testing for the prediction of small-bowel pathology detected by capsule endoscopy: a systematic review and meta-analysis |
title_full | Fecal occult blood testing for the prediction of small-bowel pathology detected by capsule endoscopy: a systematic review and meta-analysis |
title_fullStr | Fecal occult blood testing for the prediction of small-bowel pathology detected by capsule endoscopy: a systematic review and meta-analysis |
title_full_unstemmed | Fecal occult blood testing for the prediction of small-bowel pathology detected by capsule endoscopy: a systematic review and meta-analysis |
title_short | Fecal occult blood testing for the prediction of small-bowel pathology detected by capsule endoscopy: a systematic review and meta-analysis |
title_sort | fecal occult blood testing for the prediction of small-bowel pathology detected by capsule endoscopy: a systematic review and meta-analysis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320031/ https://www.ncbi.nlm.nih.gov/pubmed/28243039 http://dx.doi.org/10.20524/aog.2017.0122 |
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