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Unconventional Role of Caspase-6 in Spinal Microglia Activation and Chronic Pain
Chronic pain affects ~20% of the worldwide population. The clinical management of chronic pain is mostly palliative and results in limited success. Current treatments mostly target the symptoms or neuronal signaling of chronic pain. It has been increasingly recognized that glial cells, such as micro...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320069/ https://www.ncbi.nlm.nih.gov/pubmed/28270702 http://dx.doi.org/10.1155/2017/9383184 |
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author | Berta, Temugin Lee, Jee Eun Park, Chul-Kyu |
author_facet | Berta, Temugin Lee, Jee Eun Park, Chul-Kyu |
author_sort | Berta, Temugin |
collection | PubMed |
description | Chronic pain affects ~20% of the worldwide population. The clinical management of chronic pain is mostly palliative and results in limited success. Current treatments mostly target the symptoms or neuronal signaling of chronic pain. It has been increasingly recognized that glial cells, such as microglia, and inflammatory signaling play a major role in the pathogenesis of chronic pain. Caspases (CASPs) are a family of protease enzymes involved in apoptosis and inflammation. They are pivotal components in a variety of neurological diseases. However, little is known about the role of CASPs in microglial modulation as to chronic pain. In particular, our recent studies have shown that CASP6 regulates chronic pain via microglial inflammatory signaling. Inhibition of microglia and CASP signaling might provide a new strategy for the prevention and treatment of chronic pain. |
format | Online Article Text |
id | pubmed-5320069 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-53200692017-03-07 Unconventional Role of Caspase-6 in Spinal Microglia Activation and Chronic Pain Berta, Temugin Lee, Jee Eun Park, Chul-Kyu Mediators Inflamm Review Article Chronic pain affects ~20% of the worldwide population. The clinical management of chronic pain is mostly palliative and results in limited success. Current treatments mostly target the symptoms or neuronal signaling of chronic pain. It has been increasingly recognized that glial cells, such as microglia, and inflammatory signaling play a major role in the pathogenesis of chronic pain. Caspases (CASPs) are a family of protease enzymes involved in apoptosis and inflammation. They are pivotal components in a variety of neurological diseases. However, little is known about the role of CASPs in microglial modulation as to chronic pain. In particular, our recent studies have shown that CASP6 regulates chronic pain via microglial inflammatory signaling. Inhibition of microglia and CASP signaling might provide a new strategy for the prevention and treatment of chronic pain. Hindawi Publishing Corporation 2017 2017-02-07 /pmc/articles/PMC5320069/ /pubmed/28270702 http://dx.doi.org/10.1155/2017/9383184 Text en Copyright © 2017 Temugin Berta et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Berta, Temugin Lee, Jee Eun Park, Chul-Kyu Unconventional Role of Caspase-6 in Spinal Microglia Activation and Chronic Pain |
title | Unconventional Role of Caspase-6 in Spinal Microglia Activation and Chronic Pain |
title_full | Unconventional Role of Caspase-6 in Spinal Microglia Activation and Chronic Pain |
title_fullStr | Unconventional Role of Caspase-6 in Spinal Microglia Activation and Chronic Pain |
title_full_unstemmed | Unconventional Role of Caspase-6 in Spinal Microglia Activation and Chronic Pain |
title_short | Unconventional Role of Caspase-6 in Spinal Microglia Activation and Chronic Pain |
title_sort | unconventional role of caspase-6 in spinal microglia activation and chronic pain |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320069/ https://www.ncbi.nlm.nih.gov/pubmed/28270702 http://dx.doi.org/10.1155/2017/9383184 |
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