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TMEM187-IRAK1 Polymorphisms Associated with Rheumatoid Arthritis Susceptibility in Tunisian and French Female Populations: Influence of Geographic Origin

Polymorphisms have been identified in the Xq28 locus as risk loci for rheumatoid arthritis (RA). Here, we investigated the association between three polymorphisms in the Xq28 region containing TMEM187 and IRAK1 (rs13397, rs1059703, and rs1059702) in two unstudied populations: Tunisian and French. Th...

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Autores principales: Khalifa, Olfa, Balandraud, Nathalie, Lambert, Nathalie, Auger, Isabelle, Roudier, Jean, Sénéchal, Audrey, Geneviève, David, Picard, Christophe, Lefranc, Gérard, Touitou, Isabelle, Mrenda, Bakridine M'Madi, Benedito, Cécilia, Pardoux, Etienne, Gagez, Anne-Laure, Pers, Yves-Marie, Jorgensen, Christian, Mahjoub, Touhami, Apparailly, Florence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320318/
https://www.ncbi.nlm.nih.gov/pubmed/28271077
http://dx.doi.org/10.1155/2017/4915950
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author Khalifa, Olfa
Balandraud, Nathalie
Lambert, Nathalie
Auger, Isabelle
Roudier, Jean
Sénéchal, Audrey
Geneviève, David
Picard, Christophe
Lefranc, Gérard
Touitou, Isabelle
Mrenda, Bakridine M'Madi
Benedito, Cécilia
Pardoux, Etienne
Gagez, Anne-Laure
Pers, Yves-Marie
Jorgensen, Christian
Mahjoub, Touhami
Apparailly, Florence
author_facet Khalifa, Olfa
Balandraud, Nathalie
Lambert, Nathalie
Auger, Isabelle
Roudier, Jean
Sénéchal, Audrey
Geneviève, David
Picard, Christophe
Lefranc, Gérard
Touitou, Isabelle
Mrenda, Bakridine M'Madi
Benedito, Cécilia
Pardoux, Etienne
Gagez, Anne-Laure
Pers, Yves-Marie
Jorgensen, Christian
Mahjoub, Touhami
Apparailly, Florence
author_sort Khalifa, Olfa
collection PubMed
description Polymorphisms have been identified in the Xq28 locus as risk loci for rheumatoid arthritis (RA). Here, we investigated the association between three polymorphisms in the Xq28 region containing TMEM187 and IRAK1 (rs13397, rs1059703, and rs1059702) in two unstudied populations: Tunisian and French. The rs13397 G and rs1059703 T major alleles were significantly increased in RA patients (n = 408) compared with age-matched controls (n = 471) in both Tunisian and French women. These results were confirmed by a meta-analysis replication study including two independent Greek and Korean cohorts. The rs1059702 C major allele was significantly associated with RA, only with French women. In the French population, the GTC haplotype displayed a protective effect against RA, while the ATC, GCC, and GTT haplotypes conferred significant risk for RA. No association for these haplotypes was found in the Tunisian population. Our results replicated for the first time the association of the three Xq28 polymorphisms with RA risk in Tunisian and French populations and suggested that RA susceptibility is associated with TMEM187-IRAK1 polymorphisms in women. Our data further support the involvement of X chromosome in RA susceptibility and evidence ethnicities differences that might be explained by differences in the frequencies of SE HLA-DRB1 alleles between both populations.
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spelling pubmed-53203182017-03-07 TMEM187-IRAK1 Polymorphisms Associated with Rheumatoid Arthritis Susceptibility in Tunisian and French Female Populations: Influence of Geographic Origin Khalifa, Olfa Balandraud, Nathalie Lambert, Nathalie Auger, Isabelle Roudier, Jean Sénéchal, Audrey Geneviève, David Picard, Christophe Lefranc, Gérard Touitou, Isabelle Mrenda, Bakridine M'Madi Benedito, Cécilia Pardoux, Etienne Gagez, Anne-Laure Pers, Yves-Marie Jorgensen, Christian Mahjoub, Touhami Apparailly, Florence J Immunol Res Research Article Polymorphisms have been identified in the Xq28 locus as risk loci for rheumatoid arthritis (RA). Here, we investigated the association between three polymorphisms in the Xq28 region containing TMEM187 and IRAK1 (rs13397, rs1059703, and rs1059702) in two unstudied populations: Tunisian and French. The rs13397 G and rs1059703 T major alleles were significantly increased in RA patients (n = 408) compared with age-matched controls (n = 471) in both Tunisian and French women. These results were confirmed by a meta-analysis replication study including two independent Greek and Korean cohorts. The rs1059702 C major allele was significantly associated with RA, only with French women. In the French population, the GTC haplotype displayed a protective effect against RA, while the ATC, GCC, and GTT haplotypes conferred significant risk for RA. No association for these haplotypes was found in the Tunisian population. Our results replicated for the first time the association of the three Xq28 polymorphisms with RA risk in Tunisian and French populations and suggested that RA susceptibility is associated with TMEM187-IRAK1 polymorphisms in women. Our data further support the involvement of X chromosome in RA susceptibility and evidence ethnicities differences that might be explained by differences in the frequencies of SE HLA-DRB1 alleles between both populations. Hindawi Publishing Corporation 2017 2017-02-08 /pmc/articles/PMC5320318/ /pubmed/28271077 http://dx.doi.org/10.1155/2017/4915950 Text en Copyright © 2017 Olfa Khalifa et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Khalifa, Olfa
Balandraud, Nathalie
Lambert, Nathalie
Auger, Isabelle
Roudier, Jean
Sénéchal, Audrey
Geneviève, David
Picard, Christophe
Lefranc, Gérard
Touitou, Isabelle
Mrenda, Bakridine M'Madi
Benedito, Cécilia
Pardoux, Etienne
Gagez, Anne-Laure
Pers, Yves-Marie
Jorgensen, Christian
Mahjoub, Touhami
Apparailly, Florence
TMEM187-IRAK1 Polymorphisms Associated with Rheumatoid Arthritis Susceptibility in Tunisian and French Female Populations: Influence of Geographic Origin
title TMEM187-IRAK1 Polymorphisms Associated with Rheumatoid Arthritis Susceptibility in Tunisian and French Female Populations: Influence of Geographic Origin
title_full TMEM187-IRAK1 Polymorphisms Associated with Rheumatoid Arthritis Susceptibility in Tunisian and French Female Populations: Influence of Geographic Origin
title_fullStr TMEM187-IRAK1 Polymorphisms Associated with Rheumatoid Arthritis Susceptibility in Tunisian and French Female Populations: Influence of Geographic Origin
title_full_unstemmed TMEM187-IRAK1 Polymorphisms Associated with Rheumatoid Arthritis Susceptibility in Tunisian and French Female Populations: Influence of Geographic Origin
title_short TMEM187-IRAK1 Polymorphisms Associated with Rheumatoid Arthritis Susceptibility in Tunisian and French Female Populations: Influence of Geographic Origin
title_sort tmem187-irak1 polymorphisms associated with rheumatoid arthritis susceptibility in tunisian and french female populations: influence of geographic origin
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320318/
https://www.ncbi.nlm.nih.gov/pubmed/28271077
http://dx.doi.org/10.1155/2017/4915950
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