Development of a Novel Formulation That Improves Preclinical Bioavailability of Tenofovir Disoproxil Fumarate

Tenofovir disoproxil fumarate (TDF), the bisphosphonate ester prodrug of tenofovir (TFV), has poor bioavailability due to intestinal degradation and efflux transport. Reformulation using U.S. Food and Drug Administration–approved esterase and efflux inhibitors to increase oral bioavailability could...

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Detalles Bibliográficos
Autores principales: Watkins, Melynda E., Wring, Steve, Randolph, Ryan, Park, Seonghee, Powell, Kendall, Lutz, Lissa, Nowakowski, Michelle, Ramabhadran, Ram, Domanico, Paul L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320394/
https://www.ncbi.nlm.nih.gov/pubmed/27986599
http://dx.doi.org/10.1016/j.xphs.2016.12.003

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