A unique mechanism regulating gene expression in 1-cell embryos

After fertilization, the genome of zygotes is transcriptionally silent. The timing of the initiation of transcription is species-specific and occurs at the mid-1-cell stage in mice. Recent analyses using high-throughput sequencing (HTS) have identified thousands of genes transcribed at the 1-cell st...

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Detalles Bibliográficos
Autores principales: YAMAMOTO, Ryoma, AOKI, Fugaku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Society for Reproduction and Development 2016
Materias:
Opinions and Hypotheses
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320424/
https://www.ncbi.nlm.nih.gov/pubmed/27867162
http://dx.doi.org/10.1262/jrd.2016-133
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author YAMAMOTO, Ryoma
AOKI, Fugaku
author_facet YAMAMOTO, Ryoma
AOKI, Fugaku
author_sort YAMAMOTO, Ryoma
collection PubMed
description After fertilization, the genome of zygotes is transcriptionally silent. The timing of the initiation of transcription is species-specific and occurs at the mid-1-cell stage in mice. Recent analyses using high-throughput sequencing (HTS) have identified thousands of genes transcribed at the 1-cell stage, and the pattern of expression among these genes appears to be unique. In this article, we show the result of an additional analysis using HTS data from a previous study, and present the hypothesis that an extremely loose chromatin structure causes promiscuous gene expression in 1-cell embryos.
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spelling pubmed-53204242017-02-27 A unique mechanism regulating gene expression in 1-cell embryos YAMAMOTO, Ryoma AOKI, Fugaku J Reprod Dev Opinions and Hypotheses After fertilization, the genome of zygotes is transcriptionally silent. The timing of the initiation of transcription is species-specific and occurs at the mid-1-cell stage in mice. Recent analyses using high-throughput sequencing (HTS) have identified thousands of genes transcribed at the 1-cell stage, and the pattern of expression among these genes appears to be unique. In this article, we show the result of an additional analysis using HTS data from a previous study, and present the hypothesis that an extremely loose chromatin structure causes promiscuous gene expression in 1-cell embryos. The Society for Reproduction and Development 2016-11-18 2017-02 /pmc/articles/PMC5320424/ /pubmed/27867162 http://dx.doi.org/10.1262/jrd.2016-133 Text en ©2017 Society for Reproduction and Development This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: http://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Opinions and Hypotheses
YAMAMOTO, Ryoma
AOKI, Fugaku
A unique mechanism regulating gene expression in 1-cell embryos
title A unique mechanism regulating gene expression in 1-cell embryos
title_full A unique mechanism regulating gene expression in 1-cell embryos
title_fullStr A unique mechanism regulating gene expression in 1-cell embryos
title_full_unstemmed A unique mechanism regulating gene expression in 1-cell embryos
title_short A unique mechanism regulating gene expression in 1-cell embryos
title_sort unique mechanism regulating gene expression in 1-cell embryos
topic Opinions and Hypotheses
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320424/
https://www.ncbi.nlm.nih.gov/pubmed/27867162
http://dx.doi.org/10.1262/jrd.2016-133
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