Production of α1,3-galactosyltransferase and cytidine monophosphate-N-acetylneuraminic acid hydroxylase gene double-deficient pigs by CRISPR/Cas9 and handmade cloning

Gene-knockout pigs hold great promise as a solution to the shortage of organs from donor animals for xenotransplantation. Several groups have generated gene-knockout pigs via clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated 9 (Cas9) and somatic cell nuclear transf...

Descripción completa

Detalles Bibliográficos
Autores principales: GAO, Hanchao, ZHAO, Chengjiang, XIANG, Xi, LI, Yong, ZHAO, Yanli, LI, Zesong, PAN, Dengke, DAI, Yifan, HARA, Hidetaka, COOPER, David K.C., CAI, Zhiming, MOU, Lisha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Society for Reproduction and Development 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320426/
https://www.ncbi.nlm.nih.gov/pubmed/27725344
http://dx.doi.org/10.1262/jrd.2016-079

Ejemplares similares

Ejemplares similares