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Treatment of bisphosphonate-related osteonecrosis of the jaws – a report of seven cases

AIM OF THE STUDY: The aim of the study was to report on seven cases of BRONJ treated with surgical debridement, oral antibiotics and gentamicin-collagen sponge (Collatamp EG) placed in the bone wound. MATERIAL AND METHODS: Seven patients with 9 sites of BRONJ stage 2 were included in the study. Peri...

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Autores principales: Jakiel, Joanna, Rahnama, Mansur, Szczerba-Gwóźdź, Joanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320463/
https://www.ncbi.nlm.nih.gov/pubmed/28239288
http://dx.doi.org/10.5114/wo.2016.65610
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author Jakiel, Joanna
Rahnama, Mansur
Szczerba-Gwóźdź, Joanna
author_facet Jakiel, Joanna
Rahnama, Mansur
Szczerba-Gwóźdź, Joanna
author_sort Jakiel, Joanna
collection PubMed
description AIM OF THE STUDY: The aim of the study was to report on seven cases of BRONJ treated with surgical debridement, oral antibiotics and gentamicin-collagen sponge (Collatamp EG) placed in the bone wound. MATERIAL AND METHODS: Seven patients with 9 sites of BRONJ stage 2 were included in the study. Perioperative oral antibiotics, surgical debridement and/or sequestrotomy and gentamicin-collagen sponge (Collatamp EG) were used. Postoperative monitoring was carried out for the next 3 months. RESULTS: Three weeks after the surgery, six sites of BRONJ in five patients were treated successfully. In two patients on three sites BRONJ stage 1 was observed. Three months after surgery another two sites healed fully. In one patient there was still BRONJ stage 1, however, the area of exposed bone was visibly reduced. CONCLUSIONS: The use of surgical debridement together with oral antibiotic therapy and collagen-gentamycin sponge indicates positive results regarding the surgical treatment of BRONJ.
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spelling pubmed-53204632017-02-24 Treatment of bisphosphonate-related osteonecrosis of the jaws – a report of seven cases Jakiel, Joanna Rahnama, Mansur Szczerba-Gwóźdź, Joanna Contemp Oncol (Pozn) Original Paper AIM OF THE STUDY: The aim of the study was to report on seven cases of BRONJ treated with surgical debridement, oral antibiotics and gentamicin-collagen sponge (Collatamp EG) placed in the bone wound. MATERIAL AND METHODS: Seven patients with 9 sites of BRONJ stage 2 were included in the study. Perioperative oral antibiotics, surgical debridement and/or sequestrotomy and gentamicin-collagen sponge (Collatamp EG) were used. Postoperative monitoring was carried out for the next 3 months. RESULTS: Three weeks after the surgery, six sites of BRONJ in five patients were treated successfully. In two patients on three sites BRONJ stage 1 was observed. Three months after surgery another two sites healed fully. In one patient there was still BRONJ stage 1, however, the area of exposed bone was visibly reduced. CONCLUSIONS: The use of surgical debridement together with oral antibiotic therapy and collagen-gentamycin sponge indicates positive results regarding the surgical treatment of BRONJ. Termedia Publishing House 2017-01-12 2016 /pmc/articles/PMC5320463/ /pubmed/28239288 http://dx.doi.org/10.5114/wo.2016.65610 Text en Copyright: © 2017 Termedia Sp. z o. o. http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Original Paper
Jakiel, Joanna
Rahnama, Mansur
Szczerba-Gwóźdź, Joanna
Treatment of bisphosphonate-related osteonecrosis of the jaws – a report of seven cases
title Treatment of bisphosphonate-related osteonecrosis of the jaws – a report of seven cases
title_full Treatment of bisphosphonate-related osteonecrosis of the jaws – a report of seven cases
title_fullStr Treatment of bisphosphonate-related osteonecrosis of the jaws – a report of seven cases
title_full_unstemmed Treatment of bisphosphonate-related osteonecrosis of the jaws – a report of seven cases
title_short Treatment of bisphosphonate-related osteonecrosis of the jaws – a report of seven cases
title_sort treatment of bisphosphonate-related osteonecrosis of the jaws – a report of seven cases
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320463/
https://www.ncbi.nlm.nih.gov/pubmed/28239288
http://dx.doi.org/10.5114/wo.2016.65610
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