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Generation of Gross Chromosomal Rearrangements by a Single Engineered DNA Double Strand Break

Gross chromosomal rearrangements (GCRs), including translocations, inversions amplifications, and deletions, can be causal events leading to malignant transformation. GCRs are thought to be triggered by DNA double strand breaks (DSBs), which in turn can be spontaneous or induced by external agents (...

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Detalles Bibliográficos
Autores principales:	Qiu, Zhijun, Zhang, Zhenhua, Roschke, Anna, Varga, Tamas, Aplan, Peter D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320478/ https://www.ncbi.nlm.nih.gov/pubmed/28225067 http://dx.doi.org/10.1038/srep43156

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