Identification of novel cancer therapeutic targets using a designed and pooled shRNA library screen

Targeted cancer therapeutics aim to exploit tumor-specific, genetic vulnerabilities specifically affecting neoplastic cells without similarly affecting normal cells. Here we performed sequencing-based screening of an shRNA library on a panel of cancer cells of different origins as well as normal cel...

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Detalles Bibliográficos
Autores principales: Oliver, David, Ji, Hao, Liu, Piaomu, Gasparian, Alexander, Gardiner, Ellen, Lee, Samuel, Zenteno, Adrian, Perinskaya, Lillian O., Chen, Mengqian, Buckhaults, Phillip, Broude, Eugenia, Wyatt, Michael D., Valafar, Homayoun, Peña, Edsel, Shtutman, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320502/
https://www.ncbi.nlm.nih.gov/pubmed/28223711
http://dx.doi.org/10.1038/srep43023

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