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Novel Liver-targeted conjugates of Glycogen Phosphorylase Inhibitor PSN-357 for the Treatment of Diabetes: Design, Synthesis, Pharmacokinetic and Pharmacological Evaluations

PSN-357, an effective glycogen phosphorylase (GP) inhibitor for the treatment for type 2 diabetics, is hampered in its clinical use by the poor selectivity between the GP isoforms in liver and in skeletal muscle. In this study, by the introduction of cholic acid, 9 novel potent and liver-targeted co...

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Detalles Bibliográficos
Autores principales:	Zhang, Liying, Song, Chengjun, Miao, Guangxin, Zhao, Lianzhi, Yan, Zhiwei, Li, Jing, Wang, Youde
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320518/ https://www.ncbi.nlm.nih.gov/pubmed/28225016 http://dx.doi.org/10.1038/srep42251

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