Membrane targeting of TIRAP is negatively regulated by phosphorylation in its phosphoinositide-binding motif

Pathogen-activated Toll-like receptors (TLRs), such as TLR2 and TLR4, dimerize and move laterally across the plasma membrane to phosphatidylinositol (4,5)-bisphosphate-enriched domains. At these sites, TLRs interact with the TIR domain-containing adaptor protein (TIRAP), triggering a signaling casca...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhao, Xiaolin, Xiong, Wen, Xiao, Shuyan, Tang, Tuo-Xian, Ellena, Jeffrey F., Armstrong, Geoffrey S., Finkielstein, Carla V., Capelluto, Daniel G. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320522/
https://www.ncbi.nlm.nih.gov/pubmed/28225045
http://dx.doi.org/10.1038/srep43043

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320522/
https://www.ncbi.nlm.nih.gov/pubmed/28225045
http://dx.doi.org/10.1038/srep43043

Ejemplares similares