Intracellular drug bioavailability: a new predictor of system dependent drug disposition

Intracellular drug exposure is influenced by cell- and tissue-dependent expression of drug-transporting proteins and metabolizing enzymes. Here, we introduce the concept of intracellular bioavailability (F(ic)) as the fraction of extracellular drug available to bind intracellular targets, and we ass...

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Detalles Bibliográficos
Autores principales: Mateus, André, Treyer, Andrea, Wegler, Christine, Karlgren, Maria, Matsson, Pär, Artursson, Per
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320532/
https://www.ncbi.nlm.nih.gov/pubmed/28225057
http://dx.doi.org/10.1038/srep43047

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320532/
https://www.ncbi.nlm.nih.gov/pubmed/28225057
http://dx.doi.org/10.1038/srep43047

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