Direct binding of MEK1 and MEK2 to AKT induces Foxo1 phosphorylation, cellular migration and metastasis

Crosstalk between the ERK cascade and other signaling pathways is one of the means by which it acquires its signaling specificity. Here we identified a direct interaction of both MEK1 and MEK2 with AKT. The interaction is mediated by the proline rich domain of MEK1/2 and regulated by phosphorylation...

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Detalles Bibliográficos
Autores principales: Procaccia, Shiri, Ordan, Merav, Cohen, Izel, Bendetz-Nezer, Sarit, Seger, Rony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320536/
https://www.ncbi.nlm.nih.gov/pubmed/28225038
http://dx.doi.org/10.1038/srep43078

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320536/
https://www.ncbi.nlm.nih.gov/pubmed/28225038
http://dx.doi.org/10.1038/srep43078

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