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hBfl-1/hNOXA Interaction Studies Provide New Insights on the Role of Bfl-1 in Cancer Cell Resistance and for the Design of Novel Anticancer Agents

[Image: see text] Upregulation of antiapoptotic Bcl-2 proteins in certain tumors confers cancer cell resistance to chemotherapy or radiations. Members of the antiapoptotic Bcl-2 proteins, including Bcl-2, Mcl-1, Bcl-xL, Bcl-w, and Bfl-1, inhibit apoptosis by selectively binding to conserved α-helica...

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Detalles Bibliográficos
Autores principales:	Barile, Elisa, Marconi, Guya D., De, Surya K., Baggio, Carlo, Gambini, Luca, Salem, Ahmed F., Kashyap, Manoj K., Castro, Januario E., Kipps, Thomas J., Pellecchia, Maurizio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2016
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320539/ https://www.ncbi.nlm.nih.gov/pubmed/28026162 http://dx.doi.org/10.1021/acschembio.6b00962

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