Dibutyryl-cAMP attenuates pulmonary fibrosis by blocking myofibroblast differentiation via PKA/CREB/CBP signaling in rats with silicosis

BACKGROUND: Myofibroblasts play a major role in the synthesis of extracellular matrix (ECM) and the stimulation of these cells is thought to play an important role in the development of silicosis. The present study was undertaken to investigate the anti-fibrotic effects of dibutyryl-cAMP (db-cAMP) o...

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Detalles Bibliográficos
Autores principales: Liu, Yan, Xu, Hong, Geng, Yucong, Xu, Dingjie, Zhang, Lijuan, Yang, Yi, Wei, Zhongqiu, Zhang, Bonan, Li, Shifeng, Gao, Xuemin, Wang, Ruimin, Zhang, Xianghong, Brann, Darrell, Yang, Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320641/
https://www.ncbi.nlm.nih.gov/pubmed/28222740
http://dx.doi.org/10.1186/s12931-017-0523-z

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