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Investigations of silk fiber/calcium phosphate cement biocomposite for radial bone defect repair in rabbits

BACKGROUND: This study aimed to investigate the effects of silk fiber (SF)/calcium phosphate cement (CPC) biocomposite on repairing radial bone defects in rabbits. METHODS: Four-month-old New Zealand rabbits were selected to create a bilateral radial bone defect model and divided into four groups ac...

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Detalles Bibliográficos
Autores principales: Zhou, Lei, Hu, Chunjie, Chen, Yingjun, Xia, Shiqi, Yan, Jinglong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320665/
https://www.ncbi.nlm.nih.gov/pubmed/28222750
http://dx.doi.org/10.1186/s13018-017-0529-8
Descripción
Sumario:BACKGROUND: This study aimed to investigate the effects of silk fiber (SF)/calcium phosphate cement (CPC) biocomposite on repairing radial bone defects in rabbits. METHODS: Four-month-old New Zealand rabbits were selected to create a bilateral radial bone defect model and divided into four groups according to implanted material: SF/CPC, SF/CPC/particulate bone (PB), PB, and control (C). The specimens were removed at four and eight postoperative weeks for general observation, X-ray examination, tissue slicing, scanning electron microscopy (SEM), and biomechanical testing. RESULTS: Postoperative X-ray showed no bone defect repair in group C and different degrees of bone defect repair in the other three groups. Imaging, histology, and SEM showed the following: group SF/CPC formed fine trabecular bone in week 4, while the maximum bending load in group SF/CPC in week 4 was significantly different from those in the other groups (P < 0.05). CONCLUSIONS: SF/CPC has good biocompatibility and bone-inducing ability, demonstrating its bone defect-repairing ability.