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Investigations of silk fiber/calcium phosphate cement biocomposite for radial bone defect repair in rabbits
BACKGROUND: This study aimed to investigate the effects of silk fiber (SF)/calcium phosphate cement (CPC) biocomposite on repairing radial bone defects in rabbits. METHODS: Four-month-old New Zealand rabbits were selected to create a bilateral radial bone defect model and divided into four groups ac...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320665/ https://www.ncbi.nlm.nih.gov/pubmed/28222750 http://dx.doi.org/10.1186/s13018-017-0529-8 |
Sumario: | BACKGROUND: This study aimed to investigate the effects of silk fiber (SF)/calcium phosphate cement (CPC) biocomposite on repairing radial bone defects in rabbits. METHODS: Four-month-old New Zealand rabbits were selected to create a bilateral radial bone defect model and divided into four groups according to implanted material: SF/CPC, SF/CPC/particulate bone (PB), PB, and control (C). The specimens were removed at four and eight postoperative weeks for general observation, X-ray examination, tissue slicing, scanning electron microscopy (SEM), and biomechanical testing. RESULTS: Postoperative X-ray showed no bone defect repair in group C and different degrees of bone defect repair in the other three groups. Imaging, histology, and SEM showed the following: group SF/CPC formed fine trabecular bone in week 4, while the maximum bending load in group SF/CPC in week 4 was significantly different from those in the other groups (P < 0.05). CONCLUSIONS: SF/CPC has good biocompatibility and bone-inducing ability, demonstrating its bone defect-repairing ability. |
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