Declaring a tuberculosis outbreak over with genomic epidemiology

We report an updated method for inferring the time at which an infectious disease was transmitted between persons from a time-labelled pathogen genome phylogeny. We applied the method to 48 Mycobacterium tuberculosis genomes as part of a real-time public health outbreak investigation, demonstrating...

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Detalles Bibliográficos
Autores principales: Hatherell, Hollie-Ann, Didelot, Xavier, Pollock, Sue L., Tang, Patrick, Crisan, Anamaria, Johnston, James C., Colijn, Caroline, Gardy, Jennifer L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Microbiology Society 2016
Materias:
Short Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320671/
https://www.ncbi.nlm.nih.gov/pubmed/28348853
http://dx.doi.org/10.1099/mgen.0.000060
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author Hatherell, Hollie-Ann
Didelot, Xavier
Pollock, Sue L.
Tang, Patrick
Crisan, Anamaria
Johnston, James C.
Colijn, Caroline
Gardy, Jennifer L.
author_facet Hatherell, Hollie-Ann
Didelot, Xavier
Pollock, Sue L.
Tang, Patrick
Crisan, Anamaria
Johnston, James C.
Colijn, Caroline
Gardy, Jennifer L.
author_sort Hatherell, Hollie-Ann
collection PubMed
description We report an updated method for inferring the time at which an infectious disease was transmitted between persons from a time-labelled pathogen genome phylogeny. We applied the method to 48 Mycobacterium tuberculosis genomes as part of a real-time public health outbreak investigation, demonstrating that although active tuberculosis (TB) cases were diagnosed through 2013, no transmission events took place beyond mid-2012. Subsequent cases were the result of progression from latent TB infection to active disease, and not recent transmission. This evolutionary genomic approach was used to declare the outbreak over in January 2015.
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spelling pubmed-53206712017-03-27 Declaring a tuberculosis outbreak over with genomic epidemiology Hatherell, Hollie-Ann Didelot, Xavier Pollock, Sue L. Tang, Patrick Crisan, Anamaria Johnston, James C. Colijn, Caroline Gardy, Jennifer L. Microb Genom Short Paper We report an updated method for inferring the time at which an infectious disease was transmitted between persons from a time-labelled pathogen genome phylogeny. We applied the method to 48 Mycobacterium tuberculosis genomes as part of a real-time public health outbreak investigation, demonstrating that although active tuberculosis (TB) cases were diagnosed through 2013, no transmission events took place beyond mid-2012. Subsequent cases were the result of progression from latent TB infection to active disease, and not recent transmission. This evolutionary genomic approach was used to declare the outbreak over in January 2015. Microbiology Society 2016-05-31 /pmc/articles/PMC5320671/ /pubmed/28348853 http://dx.doi.org/10.1099/mgen.0.000060 Text en © 2016 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0) , which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
spellingShingle Short Paper
Hatherell, Hollie-Ann
Didelot, Xavier
Pollock, Sue L.
Tang, Patrick
Crisan, Anamaria
Johnston, James C.
Colijn, Caroline
Gardy, Jennifer L.
Declaring a tuberculosis outbreak over with genomic epidemiology
title Declaring a tuberculosis outbreak over with genomic epidemiology
title_full Declaring a tuberculosis outbreak over with genomic epidemiology
title_fullStr Declaring a tuberculosis outbreak over with genomic epidemiology
title_full_unstemmed Declaring a tuberculosis outbreak over with genomic epidemiology
title_short Declaring a tuberculosis outbreak over with genomic epidemiology
title_sort declaring a tuberculosis outbreak over with genomic epidemiology
topic Short Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320671/
https://www.ncbi.nlm.nih.gov/pubmed/28348853
http://dx.doi.org/10.1099/mgen.0.000060
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