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Xylitol in preventing dental caries: A systematic review and meta-analyses

Xylitol is a sugar alcohol having the properties that reduce levels of mutans streptococci (MS) in the plaque and saliva. To assess the role of xylitol in preventing dental caries. Systematic review and meta-analysis developed by Cochrane cooperation were adapted. Electronic search was carried out i...

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Autores principales: Janakiram, Chandrashekar, Deepan Kumar, C. V., Joseph, Joe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320817/
https://www.ncbi.nlm.nih.gov/pubmed/28250669
http://dx.doi.org/10.4103/0976-9668.198344
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author Janakiram, Chandrashekar
Deepan Kumar, C. V.
Joseph, Joe
author_facet Janakiram, Chandrashekar
Deepan Kumar, C. V.
Joseph, Joe
author_sort Janakiram, Chandrashekar
collection PubMed
description Xylitol is a sugar alcohol having the properties that reduce levels of mutans streptococci (MS) in the plaque and saliva. To assess the role of xylitol in preventing dental caries. Systematic review and meta-analysis developed by Cochrane cooperation were adapted. Electronic search was carried out in PubMed through the period up to 2014. Included clinical studies were done on (1) humans (2) participants include both individuals and as pairs (mother-child) (3) participants using orthodontic appliances (4) xylitol dispensed in any form (5) compare the effect of xylitol on dental caries and on other phenotype that determines the preventive effect on dental caries, such as decayed, missing, and filled (DMF/dmf) and salivary or plaque MS level. Twenty articles of the 477 articles initially identified. Among 20 studies indexed, 16 articles were accessed, systematically reviewed, and the meta-analysis was carried out. The evaluation of quality of the studies was done using risk of bias assessment tool. The quality of the studies was high risk and unclear risk for six and five trials. The meta-analysis shows a reduction in DMF/dmf with the standard mean (SM) of −1.09 (95% confidence interval [95% CI], −1.34, −0.83) comparing xylitol to all controls. The effect of DMF/dmf reduction by xylitol to fluoride varnish was with the SM of −1.87 (95% CI, −2.89, −0.84). The subgroup analysis, there was a reduction in MS count with SM of 0.30 (95% CI, 0.05, 0.56) when compared with all other caries preventive strategies; however, it was insignificant. Xylitol was found to be an effective strategy as self-applied caries preventive agent.
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spelling pubmed-53208172017-03-01 Xylitol in preventing dental caries: A systematic review and meta-analyses Janakiram, Chandrashekar Deepan Kumar, C. V. Joseph, Joe J Nat Sci Biol Med Review Article Xylitol is a sugar alcohol having the properties that reduce levels of mutans streptococci (MS) in the plaque and saliva. To assess the role of xylitol in preventing dental caries. Systematic review and meta-analysis developed by Cochrane cooperation were adapted. Electronic search was carried out in PubMed through the period up to 2014. Included clinical studies were done on (1) humans (2) participants include both individuals and as pairs (mother-child) (3) participants using orthodontic appliances (4) xylitol dispensed in any form (5) compare the effect of xylitol on dental caries and on other phenotype that determines the preventive effect on dental caries, such as decayed, missing, and filled (DMF/dmf) and salivary or plaque MS level. Twenty articles of the 477 articles initially identified. Among 20 studies indexed, 16 articles were accessed, systematically reviewed, and the meta-analysis was carried out. The evaluation of quality of the studies was done using risk of bias assessment tool. The quality of the studies was high risk and unclear risk for six and five trials. The meta-analysis shows a reduction in DMF/dmf with the standard mean (SM) of −1.09 (95% confidence interval [95% CI], −1.34, −0.83) comparing xylitol to all controls. The effect of DMF/dmf reduction by xylitol to fluoride varnish was with the SM of −1.87 (95% CI, −2.89, −0.84). The subgroup analysis, there was a reduction in MS count with SM of 0.30 (95% CI, 0.05, 0.56) when compared with all other caries preventive strategies; however, it was insignificant. Xylitol was found to be an effective strategy as self-applied caries preventive agent. Medknow Publications & Media Pvt Ltd 2017 /pmc/articles/PMC5320817/ /pubmed/28250669 http://dx.doi.org/10.4103/0976-9668.198344 Text en Copyright: © 2017 Journal of Natural Science, Biology and Medicine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Review Article
Janakiram, Chandrashekar
Deepan Kumar, C. V.
Joseph, Joe
Xylitol in preventing dental caries: A systematic review and meta-analyses
title Xylitol in preventing dental caries: A systematic review and meta-analyses
title_full Xylitol in preventing dental caries: A systematic review and meta-analyses
title_fullStr Xylitol in preventing dental caries: A systematic review and meta-analyses
title_full_unstemmed Xylitol in preventing dental caries: A systematic review and meta-analyses
title_short Xylitol in preventing dental caries: A systematic review and meta-analyses
title_sort xylitol in preventing dental caries: a systematic review and meta-analyses
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320817/
https://www.ncbi.nlm.nih.gov/pubmed/28250669
http://dx.doi.org/10.4103/0976-9668.198344
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