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Clinical characteristics and prognostic factors of patients with Stenotrophomonas maltophilia infections

INTRODUCTION: Stenotrophomonas maltophilia earlier had limited pathogenic potential, but now with growing degree of immunosuppression in general population, it is being recognized as an important nosocomial pathogen. METHODOLOGY: A retrospective 7 years study was carried out to determine the clinica...

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Autores principales: Batra, Priyam, Mathur, Purva, Misra, Mahesh C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320877/
https://www.ncbi.nlm.nih.gov/pubmed/28367030
http://dx.doi.org/10.4103/0974-2727.199639
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author Batra, Priyam
Mathur, Purva
Misra, Mahesh C.
author_facet Batra, Priyam
Mathur, Purva
Misra, Mahesh C.
author_sort Batra, Priyam
collection PubMed
description INTRODUCTION: Stenotrophomonas maltophilia earlier had limited pathogenic potential, but now with growing degree of immunosuppression in general population, it is being recognized as an important nosocomial pathogen. METHODOLOGY: A retrospective 7 years study was carried out to determine the clinical characteristics of all patients with Stenotrophomonas infections, antibiotic resistance pattern, and risk factors associated with hospital mortality. All patients with Stenotrophomonas culture positivity were identified and their medical records were reviewed. Risk factor associated with hospital mortality was analyzed. RESULTS: A total of 123 samples obtained from 88 patients were culture positive. Most patients presented with bacteremia (45, 51%) followed by pneumonia (37, 42%) and skin and soft tissue infections (6, 7%). About 23 of 88 Stenotrophomonas infected patients had co-infection. Percentage resistance to cotrimoxazole; 8 (5.4%) was lower than that for levofloxacin; 18 (12%). Twenty-eight patients died during hospital stay. Intensive Care Unit admission (P = 0.0002), mechanical ventilation (P = 0.0004), central venous catheterization (P = 0.0227), urethral catheterization (P = 0.0484), and previous antibiotic intake (P = 0.0026) were independent risk factors associated with mortality. CONCLUSION: Our findings suggest that Stenotrophomonas can cause various infections irrespective of patient's immune status and irrespective of potential source. Thus, Stenotrophomonas should be thought of as potential pathogen and its isolation should be looked with clinical suspicion.
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spelling pubmed-53208772017-04-01 Clinical characteristics and prognostic factors of patients with Stenotrophomonas maltophilia infections Batra, Priyam Mathur, Purva Misra, Mahesh C. J Lab Physicians Original Article INTRODUCTION: Stenotrophomonas maltophilia earlier had limited pathogenic potential, but now with growing degree of immunosuppression in general population, it is being recognized as an important nosocomial pathogen. METHODOLOGY: A retrospective 7 years study was carried out to determine the clinical characteristics of all patients with Stenotrophomonas infections, antibiotic resistance pattern, and risk factors associated with hospital mortality. All patients with Stenotrophomonas culture positivity were identified and their medical records were reviewed. Risk factor associated with hospital mortality was analyzed. RESULTS: A total of 123 samples obtained from 88 patients were culture positive. Most patients presented with bacteremia (45, 51%) followed by pneumonia (37, 42%) and skin and soft tissue infections (6, 7%). About 23 of 88 Stenotrophomonas infected patients had co-infection. Percentage resistance to cotrimoxazole; 8 (5.4%) was lower than that for levofloxacin; 18 (12%). Twenty-eight patients died during hospital stay. Intensive Care Unit admission (P = 0.0002), mechanical ventilation (P = 0.0004), central venous catheterization (P = 0.0227), urethral catheterization (P = 0.0484), and previous antibiotic intake (P = 0.0026) were independent risk factors associated with mortality. CONCLUSION: Our findings suggest that Stenotrophomonas can cause various infections irrespective of patient's immune status and irrespective of potential source. Thus, Stenotrophomonas should be thought of as potential pathogen and its isolation should be looked with clinical suspicion. Medknow Publications & Media Pvt Ltd 2017 /pmc/articles/PMC5320877/ /pubmed/28367030 http://dx.doi.org/10.4103/0974-2727.199639 Text en Copyright: © 2017 Journal of Laboratory Physicians http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Batra, Priyam
Mathur, Purva
Misra, Mahesh C.
Clinical characteristics and prognostic factors of patients with Stenotrophomonas maltophilia infections
title Clinical characteristics and prognostic factors of patients with Stenotrophomonas maltophilia infections
title_full Clinical characteristics and prognostic factors of patients with Stenotrophomonas maltophilia infections
title_fullStr Clinical characteristics and prognostic factors of patients with Stenotrophomonas maltophilia infections
title_full_unstemmed Clinical characteristics and prognostic factors of patients with Stenotrophomonas maltophilia infections
title_short Clinical characteristics and prognostic factors of patients with Stenotrophomonas maltophilia infections
title_sort clinical characteristics and prognostic factors of patients with stenotrophomonas maltophilia infections
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320877/
https://www.ncbi.nlm.nih.gov/pubmed/28367030
http://dx.doi.org/10.4103/0974-2727.199639
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