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Pharmacophore feature-based virtual screening for finding potent GSK-3 inhibitors using molecular docking and dynamics simulations

Glycogen synthase kinase-3 (GSK-3) is a multitasking serine/threonine protein kinase, which is associated with the pathophysiology of several diseases such as diabetes, cancer, psychiatric and neurodegenerative diseases. Tideglusib is a potent, selective, and irreversible GSK-3 inhibitor that has be...

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Detalles Bibliográficos
Autores principales:	Chauhan, Navneet, Gajjar, Anuradha, Basha, Syed Hussain
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Biomedical Informatics 2016
Materias:	Hypothesis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320924/ https://www.ncbi.nlm.nih.gov/pubmed/28293069 http://dx.doi.org/10.6026/97320630012391

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