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Post-mastectomy radiation therapy without usage of a bolus may be a reasonable option

To clarify the efficacy and toxicity of post-mastectomy radiation therapy (PMRT) without usage of a bolus, we identified 129 consecutive patients who received PMRT at the National Cancer Center Hospital East between 2003 and 2012. Seven of the 129 patients who received breast reconstruction before P...

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Autores principales: Nakamura, Naoki, Arahira, Satoko, Zenda, Sadamoto, Yoneyama, Kimiyasu, Mukai, Hirofumi, Onozawa, Masakatsu, Toshima, Masamichi, Motegi, Atsushi, Hirano, Yasuhiro, Hojo, Hidehiro, Kibe, Yuichi, Akimoto, Tetsuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321177/
https://www.ncbi.nlm.nih.gov/pubmed/27422934
http://dx.doi.org/10.1093/jrr/rrw055
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author Nakamura, Naoki
Arahira, Satoko
Zenda, Sadamoto
Yoneyama, Kimiyasu
Mukai, Hirofumi
Onozawa, Masakatsu
Toshima, Masamichi
Motegi, Atsushi
Hirano, Yasuhiro
Hojo, Hidehiro
Kibe, Yuichi
Akimoto, Tetsuo
author_facet Nakamura, Naoki
Arahira, Satoko
Zenda, Sadamoto
Yoneyama, Kimiyasu
Mukai, Hirofumi
Onozawa, Masakatsu
Toshima, Masamichi
Motegi, Atsushi
Hirano, Yasuhiro
Hojo, Hidehiro
Kibe, Yuichi
Akimoto, Tetsuo
author_sort Nakamura, Naoki
collection PubMed
description To clarify the efficacy and toxicity of post-mastectomy radiation therapy (PMRT) without usage of a bolus, we identified 129 consecutive patients who received PMRT at the National Cancer Center Hospital East between 2003 and 2012. Seven of the 129 patients who received breast reconstruction before PMRT were excluded. All patients received PMRT of 6 MV photons, without usage of a bolus. The median follow-up duration for all eligible patients was 47.7 months (range: 4.0–123.2). Local, locoregional and isolated locoregional recurrence was found in 12 (9.8%), 14 (11%) and 5 patients (4.1%), respectively. The 3- and 5-year cumulative incidence of local recurrence, locoregional recurrence and isolated locoregional recurrence was 9.2 and 10.7%, 10.8 and 12.4%, and 4.3 and 4.3%, respectively. Although Grade 2 dermatitis was found in 11 patients (9.0%), no Grade 3–4 dermatitis was found. On univariate analysis, only a non-luminal subtype was a significant predictor for local recurrence (P < 0.001). On multivariate analysis, a non-luminal subtype remained as an independent predictor for local recurrence (P = 0.003, odds ratio: 10.9, 95% confidence interval: 2.23–53.1). In conclusion, PMRT without usage of a bolus resulted in a low rate of severe acute dermatitis without an apparent increase in local recurrence. PMRT without usage of a bolus may be reasonable, especially for patients with a luminal subtype.
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spelling pubmed-53211772017-02-27 Post-mastectomy radiation therapy without usage of a bolus may be a reasonable option Nakamura, Naoki Arahira, Satoko Zenda, Sadamoto Yoneyama, Kimiyasu Mukai, Hirofumi Onozawa, Masakatsu Toshima, Masamichi Motegi, Atsushi Hirano, Yasuhiro Hojo, Hidehiro Kibe, Yuichi Akimoto, Tetsuo J Radiat Res Regular Paper To clarify the efficacy and toxicity of post-mastectomy radiation therapy (PMRT) without usage of a bolus, we identified 129 consecutive patients who received PMRT at the National Cancer Center Hospital East between 2003 and 2012. Seven of the 129 patients who received breast reconstruction before PMRT were excluded. All patients received PMRT of 6 MV photons, without usage of a bolus. The median follow-up duration for all eligible patients was 47.7 months (range: 4.0–123.2). Local, locoregional and isolated locoregional recurrence was found in 12 (9.8%), 14 (11%) and 5 patients (4.1%), respectively. The 3- and 5-year cumulative incidence of local recurrence, locoregional recurrence and isolated locoregional recurrence was 9.2 and 10.7%, 10.8 and 12.4%, and 4.3 and 4.3%, respectively. Although Grade 2 dermatitis was found in 11 patients (9.0%), no Grade 3–4 dermatitis was found. On univariate analysis, only a non-luminal subtype was a significant predictor for local recurrence (P < 0.001). On multivariate analysis, a non-luminal subtype remained as an independent predictor for local recurrence (P = 0.003, odds ratio: 10.9, 95% confidence interval: 2.23–53.1). In conclusion, PMRT without usage of a bolus resulted in a low rate of severe acute dermatitis without an apparent increase in local recurrence. PMRT without usage of a bolus may be reasonable, especially for patients with a luminal subtype. Oxford University Press 2017-01 2017-01-23 /pmc/articles/PMC5321177/ /pubmed/27422934 http://dx.doi.org/10.1093/jrr/rrw055 Text en © The Author 2016. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Radiation Oncology. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Regular Paper
Nakamura, Naoki
Arahira, Satoko
Zenda, Sadamoto
Yoneyama, Kimiyasu
Mukai, Hirofumi
Onozawa, Masakatsu
Toshima, Masamichi
Motegi, Atsushi
Hirano, Yasuhiro
Hojo, Hidehiro
Kibe, Yuichi
Akimoto, Tetsuo
Post-mastectomy radiation therapy without usage of a bolus may be a reasonable option
title Post-mastectomy radiation therapy without usage of a bolus may be a reasonable option
title_full Post-mastectomy radiation therapy without usage of a bolus may be a reasonable option
title_fullStr Post-mastectomy radiation therapy without usage of a bolus may be a reasonable option
title_full_unstemmed Post-mastectomy radiation therapy without usage of a bolus may be a reasonable option
title_short Post-mastectomy radiation therapy without usage of a bolus may be a reasonable option
title_sort post-mastectomy radiation therapy without usage of a bolus may be a reasonable option
topic Regular Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321177/
https://www.ncbi.nlm.nih.gov/pubmed/27422934
http://dx.doi.org/10.1093/jrr/rrw055
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