Cargando…
Post-mastectomy radiation therapy without usage of a bolus may be a reasonable option
To clarify the efficacy and toxicity of post-mastectomy radiation therapy (PMRT) without usage of a bolus, we identified 129 consecutive patients who received PMRT at the National Cancer Center Hospital East between 2003 and 2012. Seven of the 129 patients who received breast reconstruction before P...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321177/ https://www.ncbi.nlm.nih.gov/pubmed/27422934 http://dx.doi.org/10.1093/jrr/rrw055 |
_version_ | 1782509649744887808 |
---|---|
author | Nakamura, Naoki Arahira, Satoko Zenda, Sadamoto Yoneyama, Kimiyasu Mukai, Hirofumi Onozawa, Masakatsu Toshima, Masamichi Motegi, Atsushi Hirano, Yasuhiro Hojo, Hidehiro Kibe, Yuichi Akimoto, Tetsuo |
author_facet | Nakamura, Naoki Arahira, Satoko Zenda, Sadamoto Yoneyama, Kimiyasu Mukai, Hirofumi Onozawa, Masakatsu Toshima, Masamichi Motegi, Atsushi Hirano, Yasuhiro Hojo, Hidehiro Kibe, Yuichi Akimoto, Tetsuo |
author_sort | Nakamura, Naoki |
collection | PubMed |
description | To clarify the efficacy and toxicity of post-mastectomy radiation therapy (PMRT) without usage of a bolus, we identified 129 consecutive patients who received PMRT at the National Cancer Center Hospital East between 2003 and 2012. Seven of the 129 patients who received breast reconstruction before PMRT were excluded. All patients received PMRT of 6 MV photons, without usage of a bolus. The median follow-up duration for all eligible patients was 47.7 months (range: 4.0–123.2). Local, locoregional and isolated locoregional recurrence was found in 12 (9.8%), 14 (11%) and 5 patients (4.1%), respectively. The 3- and 5-year cumulative incidence of local recurrence, locoregional recurrence and isolated locoregional recurrence was 9.2 and 10.7%, 10.8 and 12.4%, and 4.3 and 4.3%, respectively. Although Grade 2 dermatitis was found in 11 patients (9.0%), no Grade 3–4 dermatitis was found. On univariate analysis, only a non-luminal subtype was a significant predictor for local recurrence (P < 0.001). On multivariate analysis, a non-luminal subtype remained as an independent predictor for local recurrence (P = 0.003, odds ratio: 10.9, 95% confidence interval: 2.23–53.1). In conclusion, PMRT without usage of a bolus resulted in a low rate of severe acute dermatitis without an apparent increase in local recurrence. PMRT without usage of a bolus may be reasonable, especially for patients with a luminal subtype. |
format | Online Article Text |
id | pubmed-5321177 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-53211772017-02-27 Post-mastectomy radiation therapy without usage of a bolus may be a reasonable option Nakamura, Naoki Arahira, Satoko Zenda, Sadamoto Yoneyama, Kimiyasu Mukai, Hirofumi Onozawa, Masakatsu Toshima, Masamichi Motegi, Atsushi Hirano, Yasuhiro Hojo, Hidehiro Kibe, Yuichi Akimoto, Tetsuo J Radiat Res Regular Paper To clarify the efficacy and toxicity of post-mastectomy radiation therapy (PMRT) without usage of a bolus, we identified 129 consecutive patients who received PMRT at the National Cancer Center Hospital East between 2003 and 2012. Seven of the 129 patients who received breast reconstruction before PMRT were excluded. All patients received PMRT of 6 MV photons, without usage of a bolus. The median follow-up duration for all eligible patients was 47.7 months (range: 4.0–123.2). Local, locoregional and isolated locoregional recurrence was found in 12 (9.8%), 14 (11%) and 5 patients (4.1%), respectively. The 3- and 5-year cumulative incidence of local recurrence, locoregional recurrence and isolated locoregional recurrence was 9.2 and 10.7%, 10.8 and 12.4%, and 4.3 and 4.3%, respectively. Although Grade 2 dermatitis was found in 11 patients (9.0%), no Grade 3–4 dermatitis was found. On univariate analysis, only a non-luminal subtype was a significant predictor for local recurrence (P < 0.001). On multivariate analysis, a non-luminal subtype remained as an independent predictor for local recurrence (P = 0.003, odds ratio: 10.9, 95% confidence interval: 2.23–53.1). In conclusion, PMRT without usage of a bolus resulted in a low rate of severe acute dermatitis without an apparent increase in local recurrence. PMRT without usage of a bolus may be reasonable, especially for patients with a luminal subtype. Oxford University Press 2017-01 2017-01-23 /pmc/articles/PMC5321177/ /pubmed/27422934 http://dx.doi.org/10.1093/jrr/rrw055 Text en © The Author 2016. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Radiation Oncology. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Regular Paper Nakamura, Naoki Arahira, Satoko Zenda, Sadamoto Yoneyama, Kimiyasu Mukai, Hirofumi Onozawa, Masakatsu Toshima, Masamichi Motegi, Atsushi Hirano, Yasuhiro Hojo, Hidehiro Kibe, Yuichi Akimoto, Tetsuo Post-mastectomy radiation therapy without usage of a bolus may be a reasonable option |
title | Post-mastectomy radiation therapy without usage of a bolus may be a reasonable option |
title_full | Post-mastectomy radiation therapy without usage of a bolus may be a reasonable option |
title_fullStr | Post-mastectomy radiation therapy without usage of a bolus may be a reasonable option |
title_full_unstemmed | Post-mastectomy radiation therapy without usage of a bolus may be a reasonable option |
title_short | Post-mastectomy radiation therapy without usage of a bolus may be a reasonable option |
title_sort | post-mastectomy radiation therapy without usage of a bolus may be a reasonable option |
topic | Regular Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321177/ https://www.ncbi.nlm.nih.gov/pubmed/27422934 http://dx.doi.org/10.1093/jrr/rrw055 |
work_keys_str_mv | AT nakamuranaoki postmastectomyradiationtherapywithoutusageofabolusmaybeareasonableoption AT arahirasatoko postmastectomyradiationtherapywithoutusageofabolusmaybeareasonableoption AT zendasadamoto postmastectomyradiationtherapywithoutusageofabolusmaybeareasonableoption AT yoneyamakimiyasu postmastectomyradiationtherapywithoutusageofabolusmaybeareasonableoption AT mukaihirofumi postmastectomyradiationtherapywithoutusageofabolusmaybeareasonableoption AT onozawamasakatsu postmastectomyradiationtherapywithoutusageofabolusmaybeareasonableoption AT toshimamasamichi postmastectomyradiationtherapywithoutusageofabolusmaybeareasonableoption AT motegiatsushi postmastectomyradiationtherapywithoutusageofabolusmaybeareasonableoption AT hiranoyasuhiro postmastectomyradiationtherapywithoutusageofabolusmaybeareasonableoption AT hojohidehiro postmastectomyradiationtherapywithoutusageofabolusmaybeareasonableoption AT kibeyuichi postmastectomyradiationtherapywithoutusageofabolusmaybeareasonableoption AT akimototetsuo postmastectomyradiationtherapywithoutusageofabolusmaybeareasonableoption |