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Common variants at 2q37.3, 8q24.21, 15q21.3, and 16q24.1 influence chronic lymphocytic leukemia risk
To identify novel risk variants for chronic lymphocytic leukemia (CLL) we conducted a genome-wide association study of 299,983 tagging SNPs, with validation in four additional series totaling 2,503 cases and 5,789 controls. We identified four risk loci for CLL at 2q37.3 (rs757978, FARP2; odds ratio...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321238/ https://www.ncbi.nlm.nih.gov/pubmed/20062064 http://dx.doi.org/10.1038/ng.510 |
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| author | Crowther-Swanepoel, Dalemari Broderick, Peter Di Bernardo, Maria Chiara Dobbins, Sara E Torres, María Mansouri, Mahmoud Ruiz-Ponte, Clara Enjuanes, Anna Rosenquist, Richard Carracedo, Angel Jurlander, Jesper Campo, Elias Juliusson, Gunnar Montserrat, Emilio Smedby, Karin E Dyer, Martin JS Matutes, Estella Dearden, Claire Sunter, Nicola J Hall, Andrew G Mainou-Fowler, Tryfonia Jackson, Graham H Summerfield, Geoffrey Harris, Robert J Pettitt, Andrew R Allsup, David J Bailey, James R Pratt, Guy Pepper, Chris Fegan, Chris Parker, Anton Oscier, David Allan, James M Catovsky, Daniel Houlston, Richard S |
| author_facet | Crowther-Swanepoel, Dalemari Broderick, Peter Di Bernardo, Maria Chiara Dobbins, Sara E Torres, María Mansouri, Mahmoud Ruiz-Ponte, Clara Enjuanes, Anna Rosenquist, Richard Carracedo, Angel Jurlander, Jesper Campo, Elias Juliusson, Gunnar Montserrat, Emilio Smedby, Karin E Dyer, Martin JS Matutes, Estella Dearden, Claire Sunter, Nicola J Hall, Andrew G Mainou-Fowler, Tryfonia Jackson, Graham H Summerfield, Geoffrey Harris, Robert J Pettitt, Andrew R Allsup, David J Bailey, James R Pratt, Guy Pepper, Chris Fegan, Chris Parker, Anton Oscier, David Allan, James M Catovsky, Daniel Houlston, Richard S |
| author_sort | Crowther-Swanepoel, Dalemari |
| collection | PubMed |
| description | To identify novel risk variants for chronic lymphocytic leukemia (CLL) we conducted a genome-wide association study of 299,983 tagging SNPs, with validation in four additional series totaling 2,503 cases and 5,789 controls. We identified four risk loci for CLL at 2q37.3 (rs757978, FARP2; odds ratio [OR] = 1.39; P = 2.11 x 10(-9)), 8q24.21 (rs2456449; OR = 1.26; P = 7.84 x 10(-10)), 15q21.3 (rs7169431; OR = 1.36; P = 4.74 x 10(-7)) and 16q24.1 (rs305061; OR = 1.22; P = 3.60 x 10(-7)). There was also evidence for risk loci at 15q25.2 (rs783540, CPEB1; OR = 1.18; P = 3.67 x 10(-6)) and 18q21.1 (rs1036935; OR = 1.22; P = 2.28 x 10(-6)). These data provide further evidence for genetic susceptibility to this B-cell hematological malignancy. |
| format | Online Article Text |
| id | pubmed-5321238 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2010 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-53212382017-02-22 Common variants at 2q37.3, 8q24.21, 15q21.3, and 16q24.1 influence chronic lymphocytic leukemia risk Crowther-Swanepoel, Dalemari Broderick, Peter Di Bernardo, Maria Chiara Dobbins, Sara E Torres, María Mansouri, Mahmoud Ruiz-Ponte, Clara Enjuanes, Anna Rosenquist, Richard Carracedo, Angel Jurlander, Jesper Campo, Elias Juliusson, Gunnar Montserrat, Emilio Smedby, Karin E Dyer, Martin JS Matutes, Estella Dearden, Claire Sunter, Nicola J Hall, Andrew G Mainou-Fowler, Tryfonia Jackson, Graham H Summerfield, Geoffrey Harris, Robert J Pettitt, Andrew R Allsup, David J Bailey, James R Pratt, Guy Pepper, Chris Fegan, Chris Parker, Anton Oscier, David Allan, James M Catovsky, Daniel Houlston, Richard S Nat Genet Article To identify novel risk variants for chronic lymphocytic leukemia (CLL) we conducted a genome-wide association study of 299,983 tagging SNPs, with validation in four additional series totaling 2,503 cases and 5,789 controls. We identified four risk loci for CLL at 2q37.3 (rs757978, FARP2; odds ratio [OR] = 1.39; P = 2.11 x 10(-9)), 8q24.21 (rs2456449; OR = 1.26; P = 7.84 x 10(-10)), 15q21.3 (rs7169431; OR = 1.36; P = 4.74 x 10(-7)) and 16q24.1 (rs305061; OR = 1.22; P = 3.60 x 10(-7)). There was also evidence for risk loci at 15q25.2 (rs783540, CPEB1; OR = 1.18; P = 3.67 x 10(-6)) and 18q21.1 (rs1036935; OR = 1.22; P = 2.28 x 10(-6)). These data provide further evidence for genetic susceptibility to this B-cell hematological malignancy. 2010-01-10 2010-02 /pmc/articles/PMC5321238/ /pubmed/20062064 http://dx.doi.org/10.1038/ng.510 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Crowther-Swanepoel, Dalemari Broderick, Peter Di Bernardo, Maria Chiara Dobbins, Sara E Torres, María Mansouri, Mahmoud Ruiz-Ponte, Clara Enjuanes, Anna Rosenquist, Richard Carracedo, Angel Jurlander, Jesper Campo, Elias Juliusson, Gunnar Montserrat, Emilio Smedby, Karin E Dyer, Martin JS Matutes, Estella Dearden, Claire Sunter, Nicola J Hall, Andrew G Mainou-Fowler, Tryfonia Jackson, Graham H Summerfield, Geoffrey Harris, Robert J Pettitt, Andrew R Allsup, David J Bailey, James R Pratt, Guy Pepper, Chris Fegan, Chris Parker, Anton Oscier, David Allan, James M Catovsky, Daniel Houlston, Richard S Common variants at 2q37.3, 8q24.21, 15q21.3, and 16q24.1 influence chronic lymphocytic leukemia risk |
| title | Common variants at 2q37.3, 8q24.21, 15q21.3, and 16q24.1 influence chronic lymphocytic leukemia risk |
| title_full | Common variants at 2q37.3, 8q24.21, 15q21.3, and 16q24.1 influence chronic lymphocytic leukemia risk |
| title_fullStr | Common variants at 2q37.3, 8q24.21, 15q21.3, and 16q24.1 influence chronic lymphocytic leukemia risk |
| title_full_unstemmed | Common variants at 2q37.3, 8q24.21, 15q21.3, and 16q24.1 influence chronic lymphocytic leukemia risk |
| title_short | Common variants at 2q37.3, 8q24.21, 15q21.3, and 16q24.1 influence chronic lymphocytic leukemia risk |
| title_sort | common variants at 2q37.3, 8q24.21, 15q21.3, and 16q24.1 influence chronic lymphocytic leukemia risk |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321238/ https://www.ncbi.nlm.nih.gov/pubmed/20062064 http://dx.doi.org/10.1038/ng.510 |
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