Bacterial expression, correct membrane targeting and functional folding of the HIV-1 membrane protein Vpu using a periplasmic signal peptide

Viral protein U (Vpu) is a type-III integral membrane protein encoded by Human Immunodeficiency Virus-1 (HIV- 1). It is expressed in infected host cells and plays several roles in viral progeny escape from infected cells, including down-regulation of CD4 receptors. But key structure/function questio...

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Detalles Bibliográficos
Autores principales: Deb, Arpan, Johnson, William A., Kline, Alexander P., Scott, Boston J., Meador, Lydia R., Srinivas, Dustin, Martin-Garcia, Jose M., Dörner, Katerina, Borges, Chad R., Misra, Rajeev, Hogue, Brenda G., Fromme, Petra, Mor, Tsafrir S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321405/
https://www.ncbi.nlm.nih.gov/pubmed/28225803
http://dx.doi.org/10.1371/journal.pone.0172529

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