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The ADAMTS9 gene is associated with cognitive aging in the elderly in a Taiwanese population
Evidence indicates that the pathophysiologic mechanisms associated with insulin resistance may contribute to cognitive aging and Alzheimer’s diseases. In this study, we hypothesize that single nucleotide polymorphisms (SNPs) within insulin resistance-associated genes, such as the ADAM metallopeptida...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321460/ https://www.ncbi.nlm.nih.gov/pubmed/28225792 http://dx.doi.org/10.1371/journal.pone.0172440 |
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author | Lin, Eugene Tsai, Shih-Jen Kuo, Po-Hsiu Liu, Yu-Li Yang, Albert C. Kao, Chung-Feng Yang, Cheng-Hung |
author_facet | Lin, Eugene Tsai, Shih-Jen Kuo, Po-Hsiu Liu, Yu-Li Yang, Albert C. Kao, Chung-Feng Yang, Cheng-Hung |
author_sort | Lin, Eugene |
collection | PubMed |
description | Evidence indicates that the pathophysiologic mechanisms associated with insulin resistance may contribute to cognitive aging and Alzheimer’s diseases. In this study, we hypothesize that single nucleotide polymorphisms (SNPs) within insulin resistance-associated genes, such as the ADAM metallopeptidase with thrombospondin type 1 motif 9 (ADAMTS9), glucokinase regulator (GCKR), and peroxisome proliferator activated receptor gamma (PPARG) genes, may be linked with cognitive aging independently and/or through complex interactions in an older Taiwanese population. A total of 547 Taiwanese subjects aged over 60 years from the Taiwan Biobank were analyzed. Mini-Mental State Examinations (MMSE) were administered to all subjects, and MMSE scores were used to measure cognitive functions. Our data showed that four SNPs (rs73832338, rs9985304, rs4317088, and rs9831846) in the ADAMTS9 gene were significantly associated with cognitive aging among the subjects (P = 1.5 x 10(−6) ~ 0.0002). This association remained significant after performing Bonferroni correction. Additionally, we found that interactions between the ADAMTS9 rs9985304 and ADAMTS9 rs76346246 SNPs influenced cognitive aging (P < 0.001). However, variants in the GCKR and PPARG genes had no association with cognitive aging in our study. Our study indicates that the ADAMTS9 gene may contribute to susceptibility to cognitive aging independently as well as through SNP-SNP interactions. |
format | Online Article Text |
id | pubmed-5321460 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-53214602017-03-09 The ADAMTS9 gene is associated with cognitive aging in the elderly in a Taiwanese population Lin, Eugene Tsai, Shih-Jen Kuo, Po-Hsiu Liu, Yu-Li Yang, Albert C. Kao, Chung-Feng Yang, Cheng-Hung PLoS One Research Article Evidence indicates that the pathophysiologic mechanisms associated with insulin resistance may contribute to cognitive aging and Alzheimer’s diseases. In this study, we hypothesize that single nucleotide polymorphisms (SNPs) within insulin resistance-associated genes, such as the ADAM metallopeptidase with thrombospondin type 1 motif 9 (ADAMTS9), glucokinase regulator (GCKR), and peroxisome proliferator activated receptor gamma (PPARG) genes, may be linked with cognitive aging independently and/or through complex interactions in an older Taiwanese population. A total of 547 Taiwanese subjects aged over 60 years from the Taiwan Biobank were analyzed. Mini-Mental State Examinations (MMSE) were administered to all subjects, and MMSE scores were used to measure cognitive functions. Our data showed that four SNPs (rs73832338, rs9985304, rs4317088, and rs9831846) in the ADAMTS9 gene were significantly associated with cognitive aging among the subjects (P = 1.5 x 10(−6) ~ 0.0002). This association remained significant after performing Bonferroni correction. Additionally, we found that interactions between the ADAMTS9 rs9985304 and ADAMTS9 rs76346246 SNPs influenced cognitive aging (P < 0.001). However, variants in the GCKR and PPARG genes had no association with cognitive aging in our study. Our study indicates that the ADAMTS9 gene may contribute to susceptibility to cognitive aging independently as well as through SNP-SNP interactions. Public Library of Science 2017-02-22 /pmc/articles/PMC5321460/ /pubmed/28225792 http://dx.doi.org/10.1371/journal.pone.0172440 Text en © 2017 Lin et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Lin, Eugene Tsai, Shih-Jen Kuo, Po-Hsiu Liu, Yu-Li Yang, Albert C. Kao, Chung-Feng Yang, Cheng-Hung The ADAMTS9 gene is associated with cognitive aging in the elderly in a Taiwanese population |
title | The ADAMTS9 gene is associated with cognitive aging in the elderly in a Taiwanese population |
title_full | The ADAMTS9 gene is associated with cognitive aging in the elderly in a Taiwanese population |
title_fullStr | The ADAMTS9 gene is associated with cognitive aging in the elderly in a Taiwanese population |
title_full_unstemmed | The ADAMTS9 gene is associated with cognitive aging in the elderly in a Taiwanese population |
title_short | The ADAMTS9 gene is associated with cognitive aging in the elderly in a Taiwanese population |
title_sort | adamts9 gene is associated with cognitive aging in the elderly in a taiwanese population |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321460/ https://www.ncbi.nlm.nih.gov/pubmed/28225792 http://dx.doi.org/10.1371/journal.pone.0172440 |
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