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Selectivity on-target of bromodomain chemical probes by structure-guided medicinal chemistry and chemical biology
Targeting epigenetic proteins is a rapidly growing area for medicinal chemistry and drug discovery. Recent years have seen an explosion of interest in developing small molecules binding to bromodomains, the readers of acetyl-lysine modifications. A plethora of co-crystal structures has motivated foc...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321501/ https://www.ncbi.nlm.nih.gov/pubmed/27193077 http://dx.doi.org/10.4155/fmc-2016-0059 |