Structure of a spliceosome remodelled for exon ligation

The spliceosome excises introns from pre-mRNAs in two sequential transesterifications – branching and exon ligation(1) – catalysed at a single catalytic metal site in U6 snRNA(2,)(3). The recent structures of the spliceosomal C complex(4,)(5) with the cleaved 5’-exon and lariat—3’-exon bound to the...

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Detalles Bibliográficos
Autores principales: Fica, Sebastian M., Oubridge, Chris, Galej, Wojciech P., Wilkinson, Max E., Bai, Xiao-Chen, Newman, Andrew J., Nagai, Kiyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321579/
https://www.ncbi.nlm.nih.gov/pubmed/28076345
http://dx.doi.org/10.1038/nature21078

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321579/
https://www.ncbi.nlm.nih.gov/pubmed/28076345
http://dx.doi.org/10.1038/nature21078

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