Expression of β-globin by cancer cells promotes cell survival during blood-borne dissemination

Metastasis-competent circulating tumour cells (CTCs) experience oxidative stress in the bloodstream, but their survival mechanisms are not well defined. Here, comparing single-cell RNA-Seq profiles of CTCs from breast, prostate and lung cancers, we observe consistent induction of β-globin (HBB), but...

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Detalles Bibliográficos
Autores principales: Zheng, Yu, Miyamoto, David T., Wittner, Ben S., Sullivan, James P., Aceto, Nicola, Jordan, Nicole Vincent, Yu, Min, Karabacak, Nezihi Murat, Comaills, Valentine, Morris, Robert, Desai, Rushil, Desai, Niyati, Emmons, Erin, Milner, John D., Lee, Richard J., Wu, Chin-Lee, Sequist, Lecia V., Haas, Wilhelm, Ting, David T., Toner, Mehmet, Ramaswamy, Sridhar, Maheswaran, Shyamala, Haber, Daniel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321792/
https://www.ncbi.nlm.nih.gov/pubmed/28181495
http://dx.doi.org/10.1038/ncomms14344

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